This title appears in the Scientific Report :
2016
Please use the identifier:
http://dx.doi.org/10.1016/j.jpain.2016.03.009 in citations.
Using Structural and Functional Brain Imaging to Investigate Responses to Acute Thermal Pain
Using Structural and Functional Brain Imaging to Investigate Responses to Acute Thermal Pain
Despite a fundamental interest in the relationship between structure and function, the relationships between measures of white matter microstructural coherence and functional brain responses to pain are poorly understood. We investigated whether fractional anisotropy (FA) in 2 white matter regions i...
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Personal Name(s): | Warbrick, Tracy (Corresponding author) |
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Fegers-Stollenwerk, Vera / Maximov, Ivan I. / Grinberg, Farida / Shah, N. J. | |
Contributing Institute: |
Physik der Medizinischen Bildgebung; INM-4 JARA-BRAIN; JARA-BRAIN |
Published in: | The journal of pain, 17 (2016) 7, S. 836 - 844 |
Imprint: |
New York, NY
Elsevier
2016
|
DOI: |
10.1016/j.jpain.2016.03.009 |
PubMed ID: |
27102895 |
Document Type: |
Journal Article |
Research Program: |
Neuroimaging |
Publikationsportal JuSER |
Despite a fundamental interest in the relationship between structure and function, the relationships between measures of white matter microstructural coherence and functional brain responses to pain are poorly understood. We investigated whether fractional anisotropy (FA) in 2 white matter regions in pathways associated with pain is related to the functional magnetic resonance imaging (fMRI) blood oxygen level-dependent (BOLD) response to thermal stimulation. BOLD fMRI was measured from 16 healthy male subjects during painful thermal stimulation of the right arm. Diffusion-weighted images were acquired for each subject and FA estimates were extracted from the posterior internal capsule and the cingulum (cingulate gyrus). These values were then included as covariates in the fMRI data analysis. We found BOLD response in the midcingulate cortex (MCC) to be positively related to FA in the posterior internal capsule and negatively related to FA in the cingulum. Our results suggest that the MCC's involvement in processing pain can be further delineated by considering how the magnitude of the BOLD response is related to white matter microstructural coherence and to subjective perception of pain. Considering relationships to white matter microstructural coherence in tracts involved in transmitting information to different parts of the pain network can help interpretation of MCC BOLD activation |