This title appears in the Scientific Report :
2017
Please use the identifier:
http://hdl.handle.net/2128/13538 in citations.
Please use the identifier: http://dx.doi.org/10.1016/j.nicl.2016.12.020 in citations.
The use of amino acid PET and conventional MRI for monitoring of brain tumor therapy
The use of amino acid PET and conventional MRI for monitoring of brain tumor therapy
Routine diagnostics and treatment monitoring of brain tumors is usually based on contrast-enhanced MRI. However, the capacity of conventional MRI to differentiate tumor tissue from posttherapeutic effects following neurosurgical resection, chemoradiation, alkylating chemotherapy, radiosurgery, and/o...
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Personal Name(s): | Galldiks, Norbert (Corresponding author) |
---|---|
Law, Ian / Pope, Whitney B. / Arbizu, Javier / Langen, Karl-Josef | |
Contributing Institute: |
Physik der Medizinischen Bildgebung; INM-4 Kognitive Neurowissenschaften; INM-3 |
Published in: | NeuroImage: Clinical, 13 (2017) S. 386 - 394 |
Imprint: |
[Amsterdam u.a.]
Elsevier
2017
|
PubMed ID: |
28116231 |
DOI: |
10.1016/j.nicl.2016.12.020 |
Document Type: |
Journal Article |
Research Program: |
(Dys-)function and Plasticity |
Link: |
OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1016/j.nicl.2016.12.020 in citations.
Routine diagnostics and treatment monitoring of brain tumors is usually based on contrast-enhanced MRI. However, the capacity of conventional MRI to differentiate tumor tissue from posttherapeutic effects following neurosurgical resection, chemoradiation, alkylating chemotherapy, radiosurgery, and/or immunotherapy may be limited. Metabolic imaging using PET can provide relevant additional information on tumor metabolism, which allows for more accurate diagnostics especially in clinically equivocal situations. This review article focuses predominantly on the amino acid PET tracers 11C-methyl-l-methionine (MET), O-(2-[18F]fluoroethyl)-l-tyrosine (FET) and 3,4-dihydroxy-6-[18F]-fluoro-l-phenylalanine (FDOPA) and summarizes investigations regarding monitoring of brain tumor therapy. |