Strukturelle Charakterisierung von GABARAP-Ligand-Interaktionen
Strukturelle Charakterisierung von GABARAP-Ligand-Interaktionen
Vesicular trafficking is an important homeostatic process in eukaryotic cells which criticallyrelies on membrane fusion. One of the essential components of the universal membrane fusionmachinery is NSF (N-ethylmaleimide-sensitive factor), a large hexameric ATPase involved indisassembly of SNARE (sol...
Saved in:
Personal Name(s): | Thielmann, Yvonne (Corresponding author) |
---|---|
Contributing Institute: |
Publikationen vor 2000; PRE-2000; Retrocat Zelluläre Biophysik; ISB-1 |
Imprint: |
Jülich
Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag
2009
|
Physical Description: |
Getr. Zählung : Ill., graph. Darst |
Dissertation Note: |
Universität Düsseldorf, Diss., 2009 |
ISBN: |
978-3-89336-563-0 |
Document Type: |
Book Dissertation / PhD Thesis |
Research Program: |
Addenda |
Series Title: |
Schriften des Forschungszentrums Jülich. Reihe Gesundheit / Health
12 |
Publikationsportal JuSER |
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520 | |a Vesicular trafficking is an important homeostatic process in eukaryotic cells which criticallyrelies on membrane fusion. One of the essential components of the universal membrane fusionmachinery is NSF (N-ethylmaleimide-sensitive factor), a large hexameric ATPase involved indisassembly of SNARE (soluble NSF attachment protein receptor) complexes. To improveour understanding of this sophisticated molecular machine, we have modeled the structure ofthe NSF hexamer in two alternative assemblies. Our data suggest a mechanistic concept ofthe operating mode of NSF which helps to explain the functional impact of post-translationalmodifications and mutations reported previously. Furthermore, a binding site for the ubiquitinlikeproteins GABARAP and GATE-16 has been spotted, yielding a complex with favorablesurface complementarity.2 | ||
502 | |a Universität Düsseldorf, Diss., 2009 |b Dissertation |c Universität Düsseldorf |d 2009 | ||
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