This title appears in the Scientific Report :
2017
Please use the identifier:
http://dx.doi.org/10.1002/pssa.201600729 in citations.
Fabrication of precisely aligned microwire and microchannel structures: Toward heat stimulation of guided neurites in neuronal cultures
Fabrication of precisely aligned microwire and microchannel structures: Toward heat stimulation of guided neurites in neuronal cultures
Microwire arrays are a powerful tool for the exertion of localized thermal stress on cellular networks. Combining microwire arrays with a set of orthogonal axon-guiding microchannels on-chip allows for the positioning of neurites, as well as control over their polarity. In this paper, we present a n...
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Personal Name(s): | Dang, Ka My |
---|---|
Rinklin, Philipp / Schnitker, Jan / Haberkorn, Bastian / Zobel, Kathrin / Gribaudo, Simona / Perrier, Anselme L. / Carolus, Jorne / Daenen, Michaël / Weigel, Stefan / Luksch, Harald / Offenhäusser, Andreas / Wolfrum, Bernhard (Corresponding author) | |
Contributing Institute: |
Bioelektronik; PGI-8 Bioelektronik; ICS-8 |
Published in: | Physica status solidi / A, 214 (2017) 9, S. 1600729 - |
Imprint: |
Weinheim
Wiley-VCH
2017
|
DOI: |
10.1002/pssa.201600729 |
Document Type: |
Journal Article |
Research Program: |
Engineering Cell Function |
Publikationsportal JuSER |
Microwire arrays are a powerful tool for the exertion of localized thermal stress on cellular networks. Combining microwire arrays with a set of orthogonal axon-guiding microchannels on-chip allows for the positioning of neurites, as well as control over their polarity. In this paper, we present a new fabrication approach, based on standard clean room fabrication and sacrificial layer etching, for the integration of microwire arrays into neurite guiding structures. The system permits the application of strong temperature gradients, enabling localized thermal stimulation inside microchannels. |