This title appears in the Scientific Report :
2017
Please use the identifier:
http://hdl.handle.net/2128/15853 in citations.
Please use the identifier: http://dx.doi.org/10.1016/j.nicl.2017.11.005 in citations.
Evaluation of factors influencing 18 F-FET uptake in the brain
Evaluation of factors influencing 18 F-FET uptake in the brain
PET using the amino-acid O-(2-18F-fluoroethyl)-l-tyrosine (18F-FET) is gaining increasing interest for brain tumour management. Semi-quantitative analysis of tracer uptake in brain tumours is based on the standardized uptake value (SUV) and the tumour-to-brain ratio (TBR). The aim of this study was...
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Personal Name(s): | Verger, Antoine (Corresponding author) |
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Stegmayr, Carina / Galldiks, Norbert / Van Der Gucht, Axel / Lohmann, Philipp / Stoffels, Gabriele / Shah, Nadim J. / Fink, Gereon R. / Guedj, Eric / Langen, Karl-Josef / Eickhoff, Simon | |
Contributing Institute: |
Physik der Medizinischen Bildgebung; INM-4 JARA-BRAIN; JARA-BRAIN Gehirn & Verhalten; INM-7 Kognitive Neurowissenschaften; INM-3 |
Published in: | NeuroImage: Clinical, 17 (2018) S. 491–497 |
Imprint: |
[Amsterdam u.a.]
Elsevier
2018
|
PubMed ID: |
29159062 |
DOI: |
10.1016/j.nicl.2017.11.005 |
Document Type: |
Journal Article |
Research Program: |
(Dys-)function and Plasticity |
Link: |
OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1016/j.nicl.2017.11.005 in citations.
PET using the amino-acid O-(2-18F-fluoroethyl)-l-tyrosine (18F-FET) is gaining increasing interest for brain tumour management. Semi-quantitative analysis of tracer uptake in brain tumours is based on the standardized uptake value (SUV) and the tumour-to-brain ratio (TBR). The aim of this study was to explore physiological factors that might influence the relationship of SUV of 18F-FET uptake in various brain areas, and thus affect quantification of 18F-FET uptake in brain tumours. Negative 18F-FET PET scans of 107 subjects, showing an inconspicuous brain distribution of 18F-FET, were evaluated retrospectively. Whole-brain quantitative analysis with Statistical Parametric Mapping (SPM) using parametric SUV PET images, and volumes of interest (VOIs) analysis with fronto-parietal, temporal, occipital, and cerebellar SUV background areas were performed to study the effect of age, gender, height, weight, injected activity, body mass index (BMI), and body surface area (BSA). After multivariate analysis, female gender and high BMI were found to be two independent factors associated with increased SUV of 18F-FET uptake in the brain. In women, SUVmean of 18F-FET uptake in the brain was 23% higher than in men (p < 0.01). SUVmean of 18F-FET uptake in the brain was positively correlated with BMI (r = 0.29; p < 0.01). The influence of these factors on SUV of 18F-FET was similar in all brain areas. In conclusion, SUV of 18F-FET in the normal brain is influenced by gender and weakly by BMI, but changes are similar in all brain areas. |