This title appears in the Scientific Report :
2018
Please use the identifier:
http://dx.doi.org/10.3233/JAD-170775 in citations.
Please use the identifier: http://hdl.handle.net/2128/18617 in citations.
Comprehensive characterization of the pyroglutamate Aβ induced motor neurodegenerative phenotype of TBA2.1 mice
Comprehensive characterization of the pyroglutamate Aβ induced motor neurodegenerative phenotype of TBA2.1 mice
Alzheimer’s disease (AD) is the most common neurodegenerative disorder and is being intensively investigated using a broad variety of animal models. Many of these models express mutant versions of human amyloid-β protein precursor (AβPP) that are associated with amyloid-β protein (Aβ)-induced early...
| Personal Name(s): | Dunkelmann, Tina |
|---|---|
| Schemmert, Sarah / Honold, Dominik / Teichmann, Kerstin / Butzküven, Elke / Demuth, Hans-Ulrich / Shah, N. J. / Langen, Karl-Josef / Kutzsche, Janine / Willbold, Dieter (Corresponding author) / Willuweit, Antje (Corresponding author) | |
| Contributing Institute: |
Jara-Institut Quantum Information; INM-11 JARA-BRAIN; JARA-BRAIN Physik der Medizinischen Bildgebung; INM-4 Strukturbiochemie; ICS-6 |
| Published in: | Journal of Alzheimer's disease, 63 (2018) 1, S. 115-130 |
| Imprint: |
Amsterdam
IOS Press
2018
|
| DOI: |
10.3233/JAD-170775 |
| PubMed ID: |
29578479 |
| Document Type: |
Journal Article |
| Research Program: |
Physical Basis of Diseases Neuroimaging |
| Link: |
Get full text OpenAccess Get full text OpenAccess |
| Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/18617 in citations.
| LEADER | 08485nam a2201165 a 4500 | ||
|---|---|---|---|
| 001 | 842478 | ||
| 005 | 20220930130139.0 | ||
| 024 | 7 | |a 10.3233/JAD-170775 |2 doi | |
| 024 | 7 | |a 2128/18617 |2 Handle | |
| 024 | 7 | |a pmid:29578479 |2 pmid | |
| 024 | 7 | |a WOS:000430016100011 |2 WOS | |
| 024 | 7 | |a altmetric:35033491 |2 altmetric | |
| 037 | |a FZJ-2018-00703 | ||
| 041 | |a English | ||
| 082 | |a 610 | ||
| 100 | 1 | |a Dunkelmann, Tina |0 P:(DE-Juel1)145867 |b 0 | |
| 245 | |a Comprehensive characterization of the pyroglutamate Aβ induced motor neurodegenerative phenotype of TBA2.1 mice | ||
| 260 | |a Amsterdam |c 2018 |b IOS Press | ||
| 520 | |a Alzheimer’s disease (AD) is the most common neurodegenerative disorder and is being intensively investigated using a broad variety of animal models. Many of these models express mutant versions of human amyloid-β protein precursor (AβPP) that are associated with amyloid-β protein (Aβ)-induced early onset familial AD. Most of these models, however, do not develop bold neurodegenerative pathology and the respective phenotypes. Nevertheless, this may well be essential for their suitability to identify therapeutically active compounds that have the potential for a curative or at least disease-modifying therapy in humans. In this study, the new transgenic mouse model TBA2.1 was explored in detail to increase knowledge about the neurodegenerative process induced by the presence of pyroglutamate modified human Aβ3-42 (pEAβ3-42). Analysis of the sensorimotor phenotype, motor coordination, Aβ pathology, neurodegeneration, and gliosis revealed formation and progression of severe pathology and phenotypes including massive neuronal loss in homozygous TBA2.1 mice within a few months. In contrast, the start of a slight phenotype was observed only after 21 months in heterozygous mice. These data highlight the role of pEAβ3-42 in the disease development and progression of AD. Based on the findings of this study, homozygous TBA2.1 mice can be utilized to gain deeper understanding in the underlying mechanisms of pEAβ3-42 and might be suitable as an animal model for treatment studies targeting toxic Aβ species, complementary to the well described transgenic AβPP mouse models. | ||
| 700 | 1 | |a Schemmert, Sarah |0 P:(DE-Juel1)165908 |b 1 |u fzj | |
| 700 | 1 | |a Honold, Dominik |0 P:(DE-HGF)0 |b 2 | |
| 700 | 1 | |a Teichmann, Kerstin |0 P:(DE-Juel1)164429 |b 3 | |
| 700 | 1 | |a Butzküven, Elke |0 P:(DE-HGF)0 |b 4 | |
| 700 | 1 | |a Demuth, Hans-Ulrich |0 P:(DE-HGF)0 |b 5 | |
| 700 | 1 | |a Shah, N. J. |0 P:(DE-Juel1)131794 |b 6 |u fzj | |
| 700 | 1 | |a Langen, Karl-Josef |0 P:(DE-Juel1)131777 |b 7 |u fzj | |
| 700 | 1 | |a Kutzsche, Janine |0 P:(DE-Juel1)159137 |b 8 |u fzj | |
| 700 | 1 | |a Willbold, Dieter |0 P:(DE-Juel1)132029 |b 9 |e Corresponding author |u fzj | |
| 700 | 1 | |a Willuweit, Antje |0 P:(DE-Juel1)144347 |b 10 |e Corresponding author |u fzj | |
| 773 | |a 10.3233/JAD-170775 |0 PERI:(DE-600)2070772-1 |n 1 |p 115-130 |t Journal of Alzheimer's disease |v 63 |y 2018 |x 1387-2877 | ||
| 856 | 4 | |u http://juser.fz-juelich.de/record/842478/files/P20180162%20%28002%29.pdf | |
| 856 | 4 | |u http://juser.fz-juelich.de/record/842478/files/Comprehensive%20characterization%20of%20the%20pyroglutamate%20A%CE%B2%20induced%20motor%20neurodegenerative%20phenotype%20of%20TBA2_1%20mice.pdf |y OpenAccess | |
| 856 | 4 | |u http://juser.fz-juelich.de/record/842478/files/P20180162%20%28002%29.gif?subformat=icon |x icon | |
| 856 | 4 | |u http://juser.fz-juelich.de/record/842478/files/P20180162%20%28002%29.jpg?subformat=icon-1440 |x icon-1440 | |
| 856 | 4 | |u http://juser.fz-juelich.de/record/842478/files/P20180162%20%28002%29.jpg?subformat=icon-180 |x icon-180 | |
| 856 | 4 | |u http://juser.fz-juelich.de/record/842478/files/P20180162%20%28002%29.jpg?subformat=icon-640 |x icon-640 | |
| 856 | 4 | |u http://juser.fz-juelich.de/record/842478/files/P20180162%20%28002%29.pdf?subformat=pdfa |x pdfa | |
| 856 | 4 | |u http://juser.fz-juelich.de/record/842478/files/Comprehensive%20characterization%20of%20the%20pyroglutamate%20A%CE%B2%20induced%20motor%20neurodegenerative%20phenotype%20of%20TBA2_1%20mice.pdf?subformat=pdfa |x pdfa |y OpenAccess | |
| 909 | C | O | |o oai:juser.fz-juelich.de:842478 |p openaire |p open_access |p OpenAPC |p driver |p VDB |p openCost |p dnbdelivery |
| 910 | 1 | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 0 |6 P:(DE-Juel1)145867 | |
| 910 | 1 | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 1 |6 P:(DE-Juel1)165908 | |
| 910 | 1 | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 3 |6 P:(DE-Juel1)164429 | |
| 910 | 1 | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 4 |6 P:(DE-HGF)0 | |
| 910 | 1 | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 6 |6 P:(DE-Juel1)131794 | |
| 910 | 1 | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 7 |6 P:(DE-Juel1)131777 | |
| 910 | 1 | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 8 |6 P:(DE-Juel1)159137 | |
| 910 | 1 | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 9 |6 P:(DE-Juel1)132029 | |
| 910 | 1 | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 10 |6 P:(DE-Juel1)144347 | |
| 913 | 1 | |a DE-HGF |b Key Technologies |l Decoding the Human Brain |1 G:(DE-HGF)POF3-570 |0 G:(DE-HGF)POF3-573 |2 G:(DE-HGF)POF3-500 |v Neuroimaging |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 | |
| 913 | 1 | |a DE-HGF |b Key Technologies |l BioSoft – Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences |1 G:(DE-HGF)POF3-550 |0 G:(DE-HGF)POF3-553 |2 G:(DE-HGF)POF3-500 |v Physical Basis of Diseases |x 1 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 | |
| 914 | 1 | |y 2018 | |
| 915 | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS | ||
| 915 | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences | ||
| 915 | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search | ||
| 915 | |a Creative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND 4.0 |0 LIC:(DE-HGF)CCBYNCND4 |2 HGFVOC | ||
| 915 | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b J ALZHEIMERS DIS : 2015 | ||
| 915 | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection | ||
| 915 | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded | ||
| 915 | |a IF < 5 |0 StatID:(DE-HGF)9900 |2 StatID | ||
| 915 | |a OpenAccess |0 StatID:(DE-HGF)0510 |2 StatID | ||
| 915 | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC | ||
| 915 | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database | ||
| 915 | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews | ||
| 915 | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline | ||
| 915 | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Thomson Reuters Master Journal List | ||
| 980 | 1 | |a APC | |
| 980 | 1 | |a FullTexts | |
| 980 | |a journal | ||
| 980 | |a VDB | ||
| 980 | |a I:(DE-Juel1)ICS-6-20110106 | ||
| 980 | |a I:(DE-Juel1)INM-4-20090406 | ||
| 980 | |a I:(DE-82)080010_20140620 | ||
| 980 | |a I:(DE-Juel1)INM-11-20170113 | ||
| 980 | |a APC | ||
| 980 | |a UNRESTRICTED | ||
| 536 | |a Physical Basis of Diseases |0 G:(DE-HGF)POF3-553 |c POF3-553 |f POF III |x 1 | ||
| 536 | |a Neuroimaging |0 G:(DE-HGF)POF3-573 |c POF3-573 |f POF III |x 0 | ||
| 336 | |a ARTICLE |2 BibTeX | ||
| 336 | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1569575861_21918 |2 PUB:(DE-HGF) | ||
| 336 | |a Output Types/Journal article |2 DataCite | ||
| 336 | |a article |2 DRIVER | ||
| 336 | |a Nanopartikel unedler Metalle (Mg0, Al0, Gd0, Sm0) |0 0 |2 EndNote | ||
| 336 | |a JOURNAL_ARTICLE |2 ORCID | ||
| 981 | |a I:(DE-Juel1)IBI-7-20200312 | ||
| 920 | |l yes | ||
| 920 | |k Jara-Institut Quantum Information; INM-11 |0 I:(DE-Juel1)INM-11-20170113 |l Jara-Institut Quantum Information |x 3 | ||
| 920 | |k JARA-BRAIN; JARA-BRAIN |0 I:(DE-82)080010_20140620 |l JARA-BRAIN |x 2 | ||
| 920 | |k Physik der Medizinischen Bildgebung; INM-4 |0 I:(DE-Juel1)INM-4-20090406 |l Physik der Medizinischen Bildgebung |x 1 | ||
| 920 | |k Strukturbiochemie; ICS-6 |0 I:(DE-Juel1)ICS-6-20110106 |l Strukturbiochemie |x 0 | ||
| 991 | |a Willbold, Dieter |0 P:(DE-Juel1)132029 |b 9 |e Corresponding author |u fzj | ||
| 991 | |a Kutzsche, Janine |0 P:(DE-Juel1)159137 |b 8 |u fzj | ||
| 991 | |a Langen, Karl-Josef |0 P:(DE-Juel1)131777 |b 7 |u fzj | ||
| 991 | |a Shah, N. J. |0 P:(DE-Juel1)131794 |b 6 |u fzj | ||
| 990 | |a Dunkelmann, Tina |0 P:(DE-Juel1)145867 |b 0 | ||
| 991 | |a Demuth, Hans-Ulrich |0 P:(DE-HGF)0 |b 5 | ||
| 991 | |a Willuweit, Antje |0 P:(DE-Juel1)144347 |b 10 |e Corresponding author |u fzj | ||
| 991 | |a Butzküven, Elke |0 P:(DE-HGF)0 |b 4 | ||
| 991 | |a Teichmann, Kerstin |0 P:(DE-Juel1)164429 |b 3 | ||
| 991 | |a Honold, Dominik |0 P:(DE-HGF)0 |b 2 | ||
| 991 | |a Schemmert, Sarah |0 P:(DE-Juel1)165908 |b 1 |u fzj | ||