This title appears in the Scientific Report :
2018
Please use the identifier:
http://dx.doi.org/10.7554/eLife.36953 in citations.
Please use the identifier: http://hdl.handle.net/2128/19571 in citations.
Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates
Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates
Signaling filopodia, termed cytonemes, are dynamic actin-based membrane structures that regulate the exchange of signaling molecules and their receptors within tissues. However, how cytoneme formation is regulated remains unclear. Here, we show that Wnt/PCP autocrine signaling controls the emergence...
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Personal Name(s): | Mattes, Benjamin |
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Dang, Yonglong / Greicius, Gediminas / Kaufmann, Lilian Tamara / Prunsche, Benedikt / Rosenbauer, Jakob / Stegmaier, Johannes / Mikut, Ralf / Özbek, Suat / Nienhaus, Gerd Ulrich / Schug, Alexander / Virshup, David M / Scholpp, Steffen (Corresponding author) | |
Contributing Institute: |
Jülich Supercomputing Center; JSC John von Neumann - Institut für Computing; NIC |
Published in: | eLife, 7 (2018) S. e36953 |
Imprint: |
Cambridge
eLife Sciences Publications
2018
|
PubMed ID: |
30060804 |
DOI: |
10.7554/eLife.36953 |
Document Type: |
Journal Article |
Research Program: |
Doktorand ohne besondere Förderung Computational Science and Mathematical Methods |
Link: |
OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/19571 in citations.
Signaling filopodia, termed cytonemes, are dynamic actin-based membrane structures that regulate the exchange of signaling molecules and their receptors within tissues. However, how cytoneme formation is regulated remains unclear. Here, we show that Wnt/PCP autocrine signaling controls the emergence of cytonemes, and that cytonemes subsequently control paracrine Wnt/β-catenin signal activation. Upon binding of the Wnt family member Wnt8a, the receptor tyrosine kinase Ror2 gets activated. Ror2/PCP signaling leads to induction of cytonemes, which mediate transport of Wnt8a to neighboring cells. In the Wnt receiving cells, Wnt8a on cytonemes triggers Wnt/β-catenin-dependent gene transcription and proliferation. We show that cytoneme-based Wnt transport operates in diverse processes, including zebrafish development, the murine intestinal crypt, and human cancer organoids, demonstrating that Wnt transport by cytonemes and its control via the Ror2 pathway is highly conserved in vertebrates. |