Description: Flow-Induced Transitions of Red Blood Cell Shapes under Shears

This title appears in the Scientific Report : 2018

Flow-Induced Transitions of Red Blood Cell Shapes under Shears

A recent study of red blood cells (RBCs) in shear flow [Lanotte et al., Proc. Natl. Acad. Sci. U.S.A. 113, 13289 (2016)] has demonstrated that RBCs first tumble, then roll, transit to a rolling and tumbling stomatocyte, and finally attain polylobed shapes with increasing shear rate, when the viscosi...

Personal Name(s):	Mauer, Johannes
	Mendez, Simon / Lanotte, Luca / Nicoud, Franck / Abkarian, Manouk / Gompper, Gerhard / Fedosov, Dmitry A. (Corresponding author)
Contributing Institute:	Theorie der Weichen Materie und Biophysik; ICS-2
Published in:	Physical review letters, 121 (2018) 11, S. 118103
Imprint:	College Park, Md. APS 2018
DOI:	10.1103/PhysRevLett.121.118103
PubMed ID:	30265089
Document Type:	Journal Article
Research Program:	Engineering Cell Function
Link:	OpenAccess OpenAccess
	Publikationsportal JuSER

Please use the identifier: http://dx.doi.org/10.1103/PhysRevLett.121.118103 in citations.
Please use the identifier: http://hdl.handle.net/2128/19744 in citations.

A recent study of red blood cells (RBCs) in shear flow [Lanotte et al., Proc. Natl. Acad. Sci. U.S.A. 113, 13289 (2016)] has demonstrated that RBCs first tumble, then roll, transit to a rolling and tumbling stomatocyte, and finally attain polylobed shapes with increasing shear rate, when the viscosity contrast between cytosol and blood plasma is large enough. Using two different simulation techniques, we construct a state diagram of RBC shapes and dynamics in shear flow as a function of shear rate and viscosity contrast, which is also supported by microfluidic experiments. Furthermore, we illustrate the importance of RBC shear elasticity for its dynamics in flow and show that two different kinds of membrane buckling trigger the transition between subsequent RBC states.