This title appears in the Scientific Report :
2019
Please use the identifier:
http://dx.doi.org/10.1093/cercor/bhy259 in citations.
Please use the identifier: http://hdl.handle.net/2128/21310 in citations.
Functional Connectivity Changes of Key Regions for Motor Initiation in Parkinson’s Disease
Functional Connectivity Changes of Key Regions for Motor Initiation in Parkinson’s Disease
Akinesia, a cardinal symptom of Parkinson’s disease, has been linked to abnormal activation in putamen and posterior medial frontal cortex (pMFC). However, little is known whether clinical severity of akinesia is linked to dysfunctional connectivity of these regions. Using a seed-based approach, we...
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Personal Name(s): | Hensel, Lukas |
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Hoffstaedter, Felix / Caspers, Julian / Michely, Jochen / Mathys, Christian / Heller, Julia / Eickhoff, Claudia / Reetz, Kathrin / Südmeyer, Martin / Fink, Gereon Rudolf / Schnitzler, Alfons / Grefkes, Christian / Eickhoff, Simon (Corresponding author) | |
Contributing Institute: |
JARA-BRAIN; JARA-BRAIN Strukturelle und funktionelle Organisation des Gehirns; INM-1 Gehirn & Verhalten; INM-7 Kognitive Neurowissenschaften; INM-3 |
Published in: | Cerebral cortex, 29 (2019) S. 383-396 |
Imprint: |
Oxford
Oxford Univ. Press
2019
|
PubMed ID: |
30418548 |
DOI: |
10.1093/cercor/bhy259 |
Document Type: |
Journal Article |
Research Program: |
Human Brain Project Specific Grant Agreement 2 Human Brain Project Specific Grant Agreement 1 Supercomputing and Modelling for the Human Brain (Dys-)function and Plasticity |
Link: |
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Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/21310 in citations.
Akinesia, a cardinal symptom of Parkinson’s disease, has been linked to abnormal activation in putamen and posterior medial frontal cortex (pMFC). However, little is known whether clinical severity of akinesia is linked to dysfunctional connectivity of these regions. Using a seed-based approach, we here investigated resting-state functional connectivity (RSFC) of putamen, pMFC and primary motor cortex (M1) in 60 patients with Parkinson’s disease on regular medication and 72 healthy controls. We found that in patients putamen featured decreases of connectivity for a number of cortical and subcortical areas engaged in sensorimotor and cognitive processing. In contrast, the pMFC showed reduced connectivity with a more focal cortical network involved in higher-level motor-cognition. Finally, M1 featured a selective disruption of connectivity in a network specifically connected with M1. Correlating clinical impairment with connectivity changes revealed a relationship between akinesia and reduced RSFC between pMFC and left intraparietal lobule (IPL). Together, the present study demonstrated RSFC decreases in networks for motor initiation and execution in Parkinson’s disease. Moreover, results suggest a relationship between pMFC-IPL decoupling and the manifestation of akinetic symptoms. |