Description: Chronology of motor-mediated microtubule streaming

This title appears in the Scientific Report : 2019

Chronology of motor-mediated microtubule streaming

We introduce a computer-based simulation model for coarse-grained, effective motor-mediated interaction between microtubule pairs to study the time-scales that compose cytoplasmic streaming. We characterise microtubule dynamics in two-dimensional systems by chronologically arranging five distinct pr...

Personal Name(s):	Ravichandran, Arvind
	Duman, Özer / Hoore, Masoud / Saggiorato, Guglielmo / Vliegenthart, Gerard A (Corresponding author) / Auth, Thorsten (Corresponding author) / Gompper, Gerhard (Corresponding author)
Contributing Institute:	Theorie der Weichen Materie und Biophysik; ICS-2 JARA - HPC; JARA-HPC
Published in:	eLife, 8 (2019) S. e39694
Imprint:	Cambridge eLife Sciences Publications 2019
PubMed ID:	30601119
DOI:	10.7554/eLife.39694
Document Type:	Journal Article
Research Program:	Hydrodynamics of Active Biological Systems Physical Basis of Diseases
Link:	OpenAccess OpenAccess
	Publikationsportal JuSER

Please use the identifier: http://hdl.handle.net/2128/21502 in citations.
Please use the identifier: http://dx.doi.org/10.7554/eLife.39694 in citations.

We introduce a computer-based simulation model for coarse-grained, effective motor-mediated interaction between microtubule pairs to study the time-scales that compose cytoplasmic streaming. We characterise microtubule dynamics in two-dimensional systems by chronologically arranging five distinct processes of varying duration that make up streaming, from microtubule pairs to collective dynamics. The structures found were polarity sorted due to the propulsion of antialigned microtubules. This also gave rise to the formation of large polar-aligned domains, and streaming at the domain boundaries. Correlation functions, mean squared displacements, and velocity distributions reveal a cascade of processes ultimately leading to microtubule streaming and advection, spanning multiple microtubule lengths. The characteristic times for the processes span over three orders of magnitude from fast single-microtubule processes to slow collective processes. Our approach can be used to directly test the importance of molecular components, such as motors and crosslinking proteins between microtubules, on the collective dynamics at cellular scale.