This title appears in the Scientific Report :
2018
Please use the identifier:
http://hdl.handle.net/2128/21302 in citations.
Please use the identifier: http://dx.doi.org/10.1371/journal.pone.0209613 in citations.
Uptake in non-affected bone tissue does not differ between [18F]-DCFPyL and [68Ga]-HBED-CC PSMA PET/CT
Uptake in non-affected bone tissue does not differ between [18F]-DCFPyL and [68Ga]-HBED-CC PSMA PET/CT
[68Ga]PSMA-HBED-CC and[18F]DCFPyL show a high potential for the detection of recurrent prostate cancer. While 18F-based tracers have several advantages in availability and image resolution, their sensitivity in the skeleton might be impaired by released [18F]fluoride due to its high bone affinity. I...
Saved in:
Personal Name(s): | Hammes, Jochen (Corresponding author) |
---|---|
Hohberg, Melanie / Täger, Philipp / Wild, Markus / Zlatopolskiy, Boris / Krapf, Philipp / Neumaier, Bernd / Schomäcker, Klaus / Kobe, Carsten / Schmidt, Matthias / Dietlein, Markus / Drzezga, Alexander | |
Contributing Institute: |
Molekulare Organisation des Gehirns; INM-2 Nuklearchemie; INM-5 |
Published in: | PLOS ONE, 13 (2018) 12, S. e0209613 - |
Imprint: |
San Francisco, California, US
PLOS
2018
|
PubMed ID: |
30571794 |
DOI: |
10.1371/journal.pone.0209613 |
Document Type: |
Journal Article |
Research Program: |
Neuroimaging |
Link: |
OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1371/journal.pone.0209613 in citations.
[68Ga]PSMA-HBED-CC and[18F]DCFPyL show a high potential for the detection of recurrent prostate cancer. While 18F-based tracers have several advantages in availability and image resolution, their sensitivity in the skeleton might be impaired by released [18F]fluoride due to its high bone affinity. In turn, chemically unbound trivalent 68Ga might also accumulate in osseous tissue, in cases of occupied binding sites of plasma proteins and thereby influence bone signal. |