This title appears in the Scientific Report :
2019
Please use the identifier:
http://hdl.handle.net/2128/22082 in citations.
Please use the identifier: http://dx.doi.org/10.1016/j.ultrasmedbio.2018.12.014 in citations.
Sonothrombolysis with Magnetically Targeted Microbubbles
Sonothrombolysis with Magnetically Targeted Microbubbles
Microbubble-enhanced sonothrombolysis is a promising approach to increasing the tolerability and efficacy of current pharmacological treatments for ischemic stroke. Maintaining therapeutic concentrations of microbubbles and drugs at the clot site, however, poses a challenge. The objective of this st...
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Personal Name(s): | de Saint Victor, Marie (First author) |
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Barnsley, Lester C. / Carugo, Dario / Owen, Joshua / Coussios, Constantin C. / Stride, Eleanor (Corresponding author) | |
Contributing Institute: |
Heinz Maier-Leibnitz Zentrum; MLZ Neutronenstreuung; JCNS-1 JCNS-FRM-II; JCNS-FRM-II |
Published in: | Ultrasound in medicine & biology, 45 (2019) 5, S. 1151 - 1163 |
Imprint: |
Amsterdam [u.a.]
Elsevier Science
2019
|
DOI: |
10.1016/j.ultrasmedbio.2018.12.014 |
PubMed ID: |
30773375 |
Document Type: |
Journal Article |
Research Program: |
FRM II / MLZ Jülich Centre for Neutron Research (JCNS) |
Subject (ZB): | |
Link: |
OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1016/j.ultrasmedbio.2018.12.014 in citations.
Microbubble-enhanced sonothrombolysis is a promising approach to increasing the tolerability and efficacy of current pharmacological treatments for ischemic stroke. Maintaining therapeutic concentrations of microbubbles and drugs at the clot site, however, poses a challenge. The objective of this study was to investigate the effect of magnetic microbubble targeting upon clot lysis rates in vitro. Retracted whole porcine blood clots were placed in a flow phantom of a partially occluded middle cerebral artery. The clots were treated with a combination of tissue plasminogen activator (0.75 µg/mL), magnetic microbubbles (∼107 microbubbles/mL) and ultrasound (0.5 MHz, 630-kPa peak rarefactional pressure, 0.2-Hz pulse repetition frequency, 2% duty cycle). Magnetic targeting was achieved using a single permanent magnet (0.08–0.38 T and 12-140 T/m in the region of the clot). The change in clot diameter was measured optically over the course of the experiment. Magnetic targeting produced a threefold average increase in lysis rates, and linear correlation was observed between lysis rate and total energy of acoustic emissions. |