This title appears in the Scientific Report :
2019
Please use the identifier:
http://dx.doi.org/10.3389/fncel.2019.00461 in citations.
Please use the identifier: http://hdl.handle.net/2128/23179 in citations.
Transcranial Current Stimulation Alters the Expression of Immune-Mediating Genes
Transcranial Current Stimulation Alters the Expression of Immune-Mediating Genes
Despite its extensive use in clinical studies, the molecular mechanisms underlying the effects of transcranial direct current stimulation (tDCS) remain to be elucidated. We previously described subacute effects of tDCS on immune- and stem cells in the rat brain. To investigate the more immediate eff...
Saved in:
Personal Name(s): | Rabenstein, Monika |
---|---|
Unverricht-Yeboah, Marcus / Keuters, Meike Hedwig / Pikhovych, Anton / Hucklenbroich, Joerg / Vay, Sabine Ulrike / Blaschke, Stefan / Ladwig, Anne / Walter, Helene Luise / Beiderbeck, Magdalena / Fink, Gereon Rudolf / Schroeter, Michael / Kriehuber, Ralf / Rueger, Maria Adele (Corresponding author) | |
Contributing Institute: |
Sicherheit und Strahlenschutz, Umgebungsüberwachung,Strahlenbiologie; S-US Kognitive Neurowissenschaften; INM-3 |
Published in: | Frontiers in cellular neuroscience, 13 (2019) S. 461 |
Imprint: |
Lausanne
Frontiers Research Foundation
2019
|
DOI: |
10.3389/fncel.2019.00461 |
PubMed ID: |
31708742 |
Document Type: |
Journal Article |
Research Program: |
(Dys-)function and Plasticity |
Link: |
OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/23179 in citations.
Despite its extensive use in clinical studies, the molecular mechanisms underlying the effects of transcranial direct current stimulation (tDCS) remain to be elucidated. We previously described subacute effects of tDCS on immune- and stem cells in the rat brain. To investigate the more immediate effects of tDCS regulating those cellular responses, we treated rats with a single session of either anodal or cathodal tDCS, and analyzed the gene expression by microarray; sham-stimulated rats served as control. Anodal tDCS increased expression of several genes coding for the major histocompatibility complex I (MHC I), while cathodal tDCS increased the expression of the immunoregulatory protein osteopontin (OPN). We confirmed the effects of gene upregulation by immunohistochemistry at the protein level. Thus, our data show a novel mechanism for the actions of tDCS on immune- and inflammatory processes, providing a target for future therapeutic studies. |