This title appears in the Scientific Report :
2020
Please use the identifier:
http://dx.doi.org/10.1016/j.copbio.2019.09.014 in citations.
Please use the identifier: http://hdl.handle.net/2128/23446 in citations.
Metabolic specialization in itaconic acid production: a tale of two fungi
Metabolic specialization in itaconic acid production: a tale of two fungi
Some of the oldest and most established industrial biotechnology processes involve the fungal production of organic acids. In these fungi, the transport of metabolites between cellular compartments, and their secretion, is a major factor. In this review we exemplify the importance of both mitochondr...
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Personal Name(s): | Wierckx, Nick (Corresponding author) |
---|---|
Agrimi, Gennaro / Lübeck, Peter Stephensen / Steiger, Matthias G. / Mira, Nuno Pereira / Punt, Peter J. | |
Contributing Institute: |
Biotechnologie; IBG-1 |
Published in: | Current opinion in biotechnology, 62 (2020) S. 153 - 159 |
Imprint: |
Amsterdam [u.a.]
Elsevier Science
2020
|
PubMed ID: |
31689647 |
DOI: |
10.1016/j.copbio.2019.09.014 |
Document Type: |
Journal Article |
Research Program: |
Biotechnology |
Link: |
OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/23446 in citations.
Some of the oldest and most established industrial biotechnology processes involve the fungal production of organic acids. In these fungi, the transport of metabolites between cellular compartments, and their secretion, is a major factor. In this review we exemplify the importance of both mitochondrial and plasma membrane transporters in the case of itaconic acid production in two very different fungal systems, Aspergillus and Ustilago. Homologous and heterologous overexpression of both types of transporters, and biochemical analysis of mitochondrial transporter function, show that these two fungi produce the same compound through very different pathways. The way these fungi respond to itaconate stress, especially at low pH, also differs, although this is still an open field which clearly needs additional research. |