This title appears in the Scientific Report :
2020
Please use the identifier:
http://hdl.handle.net/2128/23998 in citations.
Please use the identifier: http://dx.doi.org/10.1080/14737175.2020.1704256 in citations.
Advantages and limitations of amino acid PET for tracking therapy response in glioma patients
Advantages and limitations of amino acid PET for tracking therapy response in glioma patients
Introduction: Today, magnetic resonance imaging (MRI) is the standard method for monitoring patients with brain tumors. The ability of conventional MRI in differentiating neoplastic tissue from nonspecific, treatment-related changes after surgery, radio-, chemo- or immunotherapy, however, remains li...
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Personal Name(s): | Langen, Karl-Josef (Corresponding author) |
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Heinzel, Alexander / Lohmann, Philipp / Mottaghy, Felix M. / Galldiks, Norbert | |
Contributing Institute: |
Physik der Medizinischen Bildgebung; INM-4 Kognitive Neurowissenschaften; INM-3 |
Published in: | Expert review of neurotherapeutics, 20 (2020) 2, S. 137-146 |
Imprint: |
Abingdon
Taylor & Francis Group
2020
|
PubMed ID: |
31829748 |
DOI: |
10.1080/14737175.2020.1704256 |
Document Type: |
Journal Article |
Research Program: |
(Dys-)function and Plasticity |
Link: |
Published on 2019-12-18. Available in OpenAccess from 2020-12-18. Published on 2019-12-18. Available in OpenAccess from 2020-12-18. |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1080/14737175.2020.1704256 in citations.
Introduction: Today, magnetic resonance imaging (MRI) is the standard method for monitoring patients with brain tumors. The ability of conventional MRI in differentiating neoplastic tissue from nonspecific, treatment-related changes after surgery, radio-, chemo- or immunotherapy, however, remains limited. Therefore, advanced MRI sequences and positron emission tomography (PET) are increasingly being considered to improve decision-making.Areas covered: PET using radiolabeled amino acids has evolved into an important diagnostic tool to overcome some of the shortcomings of conventional MRI. In view of the rapidly developing novel treatment strategies, a reliable statement on the response to therapy is becoming increasingly important. This article gives an overview of the current results of PET with radiolabelled amino acids in therapy monitoring of standard therapy as well as various innovative approaches in the treatment of patients with cerebral gliomas.Expert opinion: Amino acid PET has proven to be helpful in therapy monitoring of gliomas, the costs are low in relation to the costs of therapy and the clinical benefit, and a widespread clinical use is highly desirable. |