Description: Molecular imaging and advanced MRI findings following immunotherapy in patients with brain tumors

This title appears in the Scientific Report : 2020

Molecular imaging and advanced MRI findings following immunotherapy in patients with brain tumors

Introduction: Currently, immunotherapy using vaccination strategies or oncolytic virus approaches, cell-based immunotherapy, and the blockade of immune checkpoints are under evaluation in patients with brain cancer. Here we summarize clinically significant imaging findings such as treatment-related...

Personal Name(s):	Galldiks, Norbert (Corresponding author)
	Lohmann, Philipp / Werner, Jan-Michael / Ceccon, Garry / Fink, Gereon R. / Langen, Karl-Josef
Contributing Institute:	Physik der Medizinischen Bildgebung; INM-4 Kognitive Neurowissenschaften; INM-3
Published in:	Expert review of anticancer therapy, 20 (2020) 1, S. 9-15
Imprint:	Abingdon, Oxon Taylor & Francis 2020
PubMed ID:	31842635
DOI:	10.1080/14737140.2020.1705788
Document Type:	Journal Article
Research Program:	(Dys-)function and Plasticity
Link:	Published on 2019-12-23. Available in OpenAccess from 2020-12-23. Published on 2019-12-23. Available in OpenAccess from 2020-12-23.
	Publikationsportal JuSER

Please use the identifier: http://hdl.handle.net/2128/23924 in citations.
Please use the identifier: http://dx.doi.org/10.1080/14737140.2020.1705788 in citations.

Introduction: Currently, immunotherapy using vaccination strategies or oncolytic virus approaches, cell-based immunotherapy, and the blockade of immune checkpoints are under evaluation in patients with brain cancer. Here we summarize clinically significant imaging findings such as treatment-related changes detected by advanced neuroimaging techniques following the most suitable immunotherapy options currently used in neuro-oncology. We, furthermore, provide an overview of how these advanced imaging techniques may help to overcome shortcomings of standard MRI in the assessment and follow-up of patients with brain cancer.Areas covered: The current literature on neuroimaging for immunotherapy in the field of brain tumors, with a focus on gliomas and brain metastases is summarized.Expert commentary: Data suggest that imaging parameters primarily derived from amino acid PET, diffusion- and perfusion-weighted MRI, or MR spectroscopy are particularly helpful for the evaluation of treatment response and provide valuable information for the differentiation of treatment-induced changes from actual brain tumor progression following various immunotherapy approaches.