This title appears in the Scientific Report :
2020
Please use the identifier:
http://hdl.handle.net/2128/23924 in citations.
Please use the identifier: http://dx.doi.org/10.1080/14737140.2020.1705788 in citations.
Molecular imaging and advanced MRI findings following immunotherapy in patients with brain tumors
Molecular imaging and advanced MRI findings following immunotherapy in patients with brain tumors
Introduction: Currently, immunotherapy using vaccination strategies or oncolytic virus approaches, cell-based immunotherapy, and the blockade of immune checkpoints are under evaluation in patients with brain cancer. Here we summarize clinically significant imaging findings such as treatment-related...
| Personal Name(s): | Galldiks, Norbert (Corresponding author) |
|---|---|
| Lohmann, Philipp / Werner, Jan-Michael / Ceccon, Garry / Fink, Gereon R. / Langen, Karl-Josef | |
| Contributing Institute: |
Physik der Medizinischen Bildgebung; INM-4 Kognitive Neurowissenschaften; INM-3 |
| Published in: | Expert review of anticancer therapy, 20 (2020) 1, S. 9-15 |
| Imprint: |
Abingdon, Oxon
Taylor & Francis
2020
|
| PubMed ID: |
31842635 |
| DOI: |
10.1080/14737140.2020.1705788 |
| Document Type: |
Journal Article |
| Research Program: |
(Dys-)function and Plasticity |
| Link: |
Published on 2019-12-23. Available in OpenAccess from 2020-12-23. Published on 2019-12-23. Available in OpenAccess from 2020-12-23. |
| Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1080/14737140.2020.1705788 in citations.
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| 520 | |a Introduction: Currently, immunotherapy using vaccination strategies or oncolytic virus approaches, cell-based immunotherapy, and the blockade of immune checkpoints are under evaluation in patients with brain cancer. Here we summarize clinically significant imaging findings such as treatment-related changes detected by advanced neuroimaging techniques following the most suitable immunotherapy options currently used in neuro-oncology. We, furthermore, provide an overview of how these advanced imaging techniques may help to overcome shortcomings of standard MRI in the assessment and follow-up of patients with brain cancer.Areas covered: The current literature on neuroimaging for immunotherapy in the field of brain tumors, with a focus on gliomas and brain metastases is summarized.Expert commentary: Data suggest that imaging parameters primarily derived from amino acid PET, diffusion- and perfusion-weighted MRI, or MR spectroscopy are particularly helpful for the evaluation of treatment response and provide valuable information for the differentiation of treatment-induced changes from actual brain tumor progression following various immunotherapy approaches. | ||
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