Kernchemische Untersuchungen zur Produktion einiger medizinisch relevanter Strontium- und Rubidium-Isotope
Kernchemische Untersuchungen zur Produktion einiger medizinisch relevanter Strontium- und Rubidium-Isotope
In palliative pain therapy of cancer patients with bone metastases the longer-lived $\beta^{-}$-emitter$^{89}$Sr (T$_{1/2}$ = 50.5 d) is often used. However, since corpuscular radiation cannot be measuredfrom outside the body, there is a lack of biodistribution data. The radiation dose caused to the...
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Personal Name(s): | Kastleiner, Sascha (Corresponding author) |
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Contributing Institute: |
Institut für Nuklearchemie; INC Publikationen vor 2000; PRE-2000; Retrocat |
Imprint: |
Jülich
Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag
2001
|
Physical Description: |
X, 101 p. |
Document Type: |
Report Book |
Research Program: |
Addenda |
Series Title: |
Berichte des Forschungszentrums Jülich
3931 |
Link: |
OpenAccess OpenAccess |
Publikationsportal JuSER |
In palliative pain therapy of cancer patients with bone metastases the longer-lived $\beta^{-}$-emitter$^{89}$Sr (T$_{1/2}$ = 50.5 d) is often used. However, since corpuscular radiation cannot be measuredfrom outside the body, there is a lack of biodistribution data. The radiation dose caused to thepatient is therefore estimated rather empirically. The shorter-lived positron-emitter $^{83}$Sr($_{T1/2}$ = 32.4 h, I$_{\beta^+}$ = 24 %) offers the possibility of quantitative investigation of the biokinetics viaPET studier, allowing thereby a better estimation of the dose. In this work, the possibility ofproduction of $^{83}$Sr by proton induced reaction an highly enriched $^{85}$Rb was investigated andcompared with the known production method $^{82}$Kr($^{3}$He,2n) $^{83}$Sr. For this purpose, extensivenuclear data measurements an the $^{85}$Rb(p,p' xn)- and $^{85}$Rb(p,xn)-reactions, leading to theformation of the isotopes $^{84m, g}$Rb, $^{83}$Rb, $^{82}$Rb, $^{81}$Rb and $^{85m, g}$Sr, $^{83}$Sr, $^{82}$Sr, $^{81}$Sr, were done.From the measured excitation functions the expected theoretical yields could be calculatedand the optimum conditions for the production of $^{83}$Sr were deduced. The optimum energyrange was found to be E$_{p}$ = 35 $\rightarrow$ 30 MeV, with $^{83}$Sr thick target yield of > 90 MBq/$\mu$Ah andthe isotopic impurity of < 0.3 % $^{85g}$Sr. In an integral test these data were confirmed. Theseresults were compared with the production of $^{83}$Sr via the $^{82}$Kr($^{3}$He,2n)-process. From theknown excitation functions the expected yields and isotopic impurities were determined andfavourable energy ranges estimated. In the energy range of 30 $\rightarrow$ 25 MeV the yield of $^{83}$Sramounted to 10 MBq/$\mu$Ah and the $^{82}$Sr-impurity to > 10 %. This impurity is much lower inthe energy range of 18 $\rightarrow$ 10 MeV (< 1 %), however, the yield of $^{83}$Sr is reduced to5 MBq/$\mu$Ah. The chemical separation of radioisotopes was performed using HPLC in the caseof data measurements and liquid chromatography in production irradiations. The chemicalyields were $\approx$ 100%. The experimentally determined cross section data were compared withtheoretical calculations, using the hybrid model code ALICE-IPPE 1996. They were in goodagreement. The determination of the isomeric cross section ratios of the isomer pairs $^{85m,g}$Srand $^{84m, g}$Rb confirmed the previous observation that with the increasing energy of theprojectile the isomeric state with the higher spin ($^{85g}$Sr with spin 9/2$^{+}$ and $^{84g}$Rb with spin 6$^{-}$)is favoured as compared to the state with the lower spin ($^{85m}$Sr with Spin 1/2$^{-}$ and $^{84m}$Rb withSpin 2$^{-}$). |