This title appears in the Scientific Report : 2020 

The genetic architecture of the human cerebral cortex.
Grasby, Katrina L (Corresponding author)
Jahanshad, Neda (Corresponding author) / Painter, Jodie N (Corresponding author) / Colodro-Conde, Lucía (Corresponding author) / Bralten, Janita (Corresponding author) / Hibar, Derrek P (Corresponding author) / Lind, Penelope A (Corresponding author) / Pizzagalli, Fabrizio (Corresponding author) / Ching, Christopher R K / McMahon, Mary Agnes B / Shatokhina, Natalia / Zsembik, Leo C P / Thomopoulos, Sophia I / Zhu, Alyssa H / Strike, Lachlan T / Agartz, Ingrid / Alhusaini, Saud / Almeida, Marcio A A / Alnæs, Dag / Amlien, Inge K / Andersson, Micael / Ard, Tyler / Armstrong, Nicola J / Ashley-Koch, Allison / Atkins, Joshua R / Bernard, Manon / Brouwer, Rachel M / Buimer, Elizabeth E L / Bülow, Robin / Bürger, Christian / Cannon, Dara M / Chakravarty, Mallar / Chen, Qiang / Cheung, Joshua W / Couvy-Duchesne, Baptiste / Dale, Anders M / Dalvie, Shareefa / de Araujo, Tânia K / de Zubicaray, Greig I / de Zwarte, Sonja M C / den Braber, Anouk / Doan, Nhat Trung / Dohm, Katharina / Ehrlich, Stefan / Engelbrecht, Hannah-Ruth / Erk, Susanne / Fan, Chun Chieh / Fedko, Iryna O / Foley, Sonya F / Ford, Judith M / Fukunaga, Masaki / Garrett, Melanie E / Ge, Tian / Giddaluru, Sudheer / Goldman, Aaron L / Green, Melissa J / Groenewold, Nynke A / Grotegerd, Dominik / Gurholt, Tiril P / Gutman, Boris A / Hansell, Narelle K / Harris, Mathew A / Harrison, Marc B / Haswell, Courtney C / Hauser, Michael / Herms, Stefan / Heslenfeld, Dirk J / Ho, New Fei / Hoehn, David / Hoffmann, Per / Holleran, Laurena / Hoogman, Martine / Hottenga, Jouke-Jan / Ikeda, Masashi / Janowitz, Deborah / Jansen, Iris E / Jia, Tianye / Jockwitz, Christiane / Kanai, Ryota / Karama, Sherif / Kasperaviciute, Dalia / Kaufmann, Tobias / Kelly, Sinead / Kikuchi, Masataka / Klein, Marieke / Knapp, Michael / Knodt, Annchen R / Krämer, Bernd / Lam, Max / Lancaster, Thomas M / Lee, Phil H / Lett, Tristram A / Lewis, Lindsay B / Lopes-Cendes, Iscia / Luciano, Michelle / Macciardi, Fabio / Marquand, Andre F / Mathias, Samuel R / Melzer, Tracy R / Milaneschi, Yuri / Mirza-Schreiber, Nazanin / Moreira, Jose C V / Mühleisen, Thomas W / Müller-Myhsok, Bertram / Najt, Pablo / Nakahara, Soichiro / Nho, Kwangsik / Olde Loohuis, Loes M / Orfanos, Dimitri Papadopoulos / Pearson, John F / Pitcher, Toni L / Pütz, Benno / Quidé, Yann / Ragothaman, Anjanibhargavi / Rashid, Faisal M / Reay, William R / Redlich, Ronny / Reinbold, Céline S / Repple, Jonathan / Richard, Geneviève / Riedel, Brandalyn C / Risacher, Shannon L / Rocha, Cristiane S / Mota, Nina Roth / Salminen, Lauren / Saremi, Arvin / Saykin, Andrew J / Schlag, Fenja / Schmaal, Lianne / Schofield, Peter R / Secolin, Rodrigo / Shapland, Chin Yang / Shen, Li / Shin, Jean / Shumskaya, Elena / Sønderby, Ida E / Sprooten, Emma / Tansey, Katherine E / Teumer, Alexander / Thalamuthu, Anbupalam / Tordesillas-Gutiérrez, Diana / Turner, Jessica A / Uhlmann, Anne / Vallerga, Costanza Ludovica / van der Meer, Dennis / van Donkelaar, Marjolein M J / van Eijk, Liza / van Erp, Theo G M / van Haren, Neeltje E M / van Rooij, Daan / van Tol, Marie-José / Veldink, Jan H / Verhoef, Ellen / Walton, Esther / Wang, Mingyuan / Wang, Yunpeng / Wardlaw, Joanna M / Wen, Wei / Westlye, Lars T / Whelan, Christopher D / Witt, Stephanie H / Wittfeld, Katharina / Wolf, Christiane / Wolfers, Thomas / Wu, Jing Qin / Yasuda, Clarissa L / Zaremba, Dario / Zhang, Zuo / Zwiers, Marcel P / Artiges, Eric / Assareh, Amelia A / Ayesa-Arriola, Rosa / Belger, Aysenil / Brandt, Christine L / Brown, Gregory G / Cichon, Sven / Curran, Joanne E / Davies, Gareth E / Degenhardt, Franziska / Dennis, Michelle F / Dietsche, Bruno / Djurovic, Srdjan / Doherty, Colin P / Espiritu, Ryan / Garijo, Daniel / Gil, Yolanda / Gowland, Penny A / Green, Robert C / Häusler, Alexander N / Heindel, Walter / Ho, Beng-Choon / Hoffmann, Wolfgang U / Holsboer, Florian / Homuth, Georg / Hosten, Norbert / Jack, Clifford R / Jang, MiHyun / Jansen, Andreas / Kimbrel, Nathan A / Kolskår, Knut / Koops, Sanne / Krug, Axel / Lim, Kelvin O / Luykx, Jurjen J / Mathalon, Daniel H / Mather, Karen A / Mattay, Venkata S / Matthews, Sarah / Mayoral Van Son, Jaqueline / McEwen, Sarah C / Melle, Ingrid / Morris, Derek W / Mueller, Bryon A / Nauck, Matthias / Nordvik, Jan E / Nöthen, Markus M / O'Leary, Daniel S / Opel, Nils / Martinot, Marie-Laure Paillère / Pike, G Bruce / Preda, Adrian / Quinlan, Erin B / Rasser, Paul E / Ratnakar, Varun / Reppermund, Simone / Steen, Vidar M / Tooney, Paul A / Torres, Fábio R / Veltman, Dick J / Voyvodic, James T / Whelan, Robert / White, Tonya / Yamamori, Hidenaga / Adams, Hieab H H / Bis, Joshua C / Debette, Stephanie / Decarli, Charles / Fornage, Myriam / Gudnason, Vilmundur / Hofer, Edith / Ikram, M Arfan / Launer, Lenore / Longstreth, W. T. / Lopez, Oscar L / Mazoyer, Bernard / Mosley, Thomas H / Roshchupkin, Gennady V / Satizabal, Claudia L / Schmidt, Reinhold / Seshadri, Sudha / Yang, Qiong / Initiative, Alzheimer’s Disease Neuroimaging (Collaboration Author) / Consortium, CHARGE (Collaboration Author) / Consortium, EPIGEN (Collaboration Author) / Consortium, IMAGEN (Collaboration Author) / Consortium, SYS (Collaboration Author) / Initiative, Parkinson’s Progression Markers (Collaboration Author) / Alvim, Marina K M / Ames, David / Anderson, Tim J / Andreassen, Ole A / Arias-Vasquez, Alejandro / Bastin, Mark E / Baune, Bernhard T / Beckham, Jean C / Blangero, John / Boomsma, Dorret I / Brodaty, Henry / Brunner, Han G / Buckner, Randy L / Buitelaar, Jan K / Bustillo, Juan R / Cahn, Wiepke / Cairns, Murray J / Calhoun, Vince / Carr, Vaughan J / Caseras, Xavier / Caspers, Svenja / Cavalleri, Gianpiero L / Cendes, Fernando / Corvin, Aiden / Crespo-Facorro, Benedicto / Dalrymple-Alford, John C / Dannlowski, Udo / de Geus, Eco J C / Deary, Ian J / Delanty, Norman / Depondt, Chantal / Desrivières, Sylvane / Donohoe, Gary / Espeseth, Thomas / Fernández, Guillén / Fisher, Simon E / Flor, Herta / Forstner, Andreas J / Francks, Clyde / Franke, Barbara / Glahn, David C / Gollub, Randy L / Grabe, Hans J / Gruber, Oliver / Håberg, Asta K / Hariri, Ahmad R / Hartman, Catharina A / Hashimoto, Ryota / Heinz, Andreas / Henskens, Frans A / Hillegers, Manon H J / Hoekstra, Pieter J / Holmes, Avram J / Hong, L Elliot / Hopkins, William D / Hulshoff Pol, Hilleke E / Jernigan, Terry L / Jönsson, Erik G / Kahn, René S / Kennedy, Martin A / Kircher, Tilo T J / Kochunov, Peter / Kwok, John B J / Le Hellard, Stephanie / Loughland, Carmel M / Martin, Nicholas G / Martinot, Jean-Luc / McDonald, Colm / McMahon, Katie L / Meyer-Lindenberg, Andreas / Michie, Patricia T / Morey, Rajendra A / Mowry, Bryan / Nyberg, Lars / Oosterlaan, Jaap / Ophoff, Roel A / Pantelis, Christos / Paus, Tomas / Pausova, Zdenka / Penninx, Brenda W J H / Polderman, Tinca J C / Posthuma, Danielle / Rietschel, Marcella / Roffman, Joshua L / Rowland, Laura M / Sachdev, Perminder S / Sämann, Philipp G / Schall, Ulrich / Schumann, Gunter / Scott, Rodney J / Sim, Kang / Sisodiya, Sanjay M / Smoller, Jordan W / Sommer, Iris E / St Pourcain, Beate / Stein, Dan J / Toga, Arthur W / Trollor, Julian N / Van der Wee, Nic J A / van 't Ent, Dennis / Völzke, Henry / Walter, Henrik / Weber, Bernd / Weinberger, Daniel R / Wright, Margaret J / Zhou, Juan / Stein, Jason L / Thompson, Paul M / Medland, Sarah E / Consortium, Enhancing NeuroImaging Genetics through Meta-Analysis (Collaboration Author) / Witte, A Veronica / Darin, Abigail / Fleisher, Adam / Pierce, Aimee / Mintz, Akiva / Lerner, Alan / Reith, Alastair D / Hofman, Albert / Espay, Alberto / Ihlenfeld, Albrecht / Ing, Alex / Iranzo, Alex / Beiser, Alexa S / Norbash, Alexander / Teumer, Alexander / Barbot, Alexis / Rudolph, Alice / Portillo, Alicia / Chalker, Alison / Levey, Allan I / Rosen, Allyson / Smith, Amanda / Catafau, Ana / Ulysse, Anaztasia / Thalamuthu, Anbupalam / Dale, Anders M / Uitterlinden, André G / Becker, Andreas / Heinz, Andreas / Budson, Andrew E / Saykin, Andrew J / Kertesz, Andrew / Siderowf, Andrew / Singleton, Andrew / James, Angela / Oliver, Angela / Mishra, Aniket / Hake, Ann Marie / Burke, Anna / Sarrael, Antero / Porsteinsson, Anton P / Stringaris, Argyris / McCoy, Arita / Villringer, Arno / Lenahan, Art / Toga, Arthur / Toga, Arthur W / Bokde, Arun / Rawlins, Ashlee / Lamb, Ashley / Lee, Athena / Raj, Balebail Ashok / Tran, Baochan / Ruggeri, Barbara / Saba, Barbara / Lane, Barton / Yanez, Beatriz / Ances, Beau / Dunlop, Becky / Mudge, Benita / Mazoyer, Bernard / Ravina, Bernard / Ittermann, Bernd / van Noort, Betteke / Lind, Betty / Shah, Bina / Stefanovic, Bojana / Goldstein, Bonnie S / Bonakdarpour, Borna / Matthews, Brandy R / Borowski, Bret / Ott, Brian R / Reynolds, Brigid / Mollenhauer, Brit / Miller, Bruce L / Psaty, Bruce M / Spann, Bryan M / Sadowsky, Carl / Linder, Carly / Franz, Carol E / Tanner, Caroline / Kopil, Catherine / Thomas, Cathi-Ann / Ward, Chad / Bernick, Charles / Smith, Charles D / DeCarli, Charles / Caspell, Chelsea / Deeley, Cheryl / Riordan, Cheryl / Mathis, Chet / Onyike, Chiadi / Heyn, Chris Chinthaka / Hosein, Chris / Leach, Christi / Bÿchel, Christian / Gigliotti, Christina / Hunter, Christine / Belden, Christine M / Tzourio, Christophe / Coffey, Christopher / van Dyck, Christopher H / Clark, Christopher M / Wu, Chuang-Kuo / Satizabal, Claudia L / Jack, Clifford R / Albers, Colleen S / Chu, Congying / Brand, Connie / Isensee, Corinna / van Duijn, Cornelia M / Bishop, Courtney / Bodge, Courtney / Tatsuoka, Curtis / Casaceli, Cynthia / Carlsson, Cynthia M / Mathews, Dana / D'Agostino, Daniel / Silverman, Daniel H S / Marson, Daniel / Berg, Daniela / Harvey, Danielle / Jennings, Danna / Wolk, David A / Ames, David / Goldstein, David B / Bachman, David / Brooks, David / Clark, David / Geldmacher, David / Hart, David / Holtzman, David / Jones, David / Knopman, David / Hewitt, David L / Perry, David / Russell, David / Standaert, David / Winkfield, David / Green, Davis Robert C / Fontaine, Deborah / Miller, Delwyn D / Gessert, Devon / Kerwin, Diana / Willeke, Diana / Drost, Dick / Papadopoulos, Dimitri / Rowe, Dominic / Simpson, Donna M / Muni, Donna / Galasko, Douglas / Scharre, Douglas W / Fillmer, Ariane / Bartha, Rob / Celmins, Dzintra / Zimmerman, Earl A / Hofer, Edith / Teng, Edmond / Tolosa, Eduardo / Coleman, Edward / Zamrini, Edward / Mitsis, Effie / Finger, Elizabeth / Oates, Elizabeth / Sosa, Elizabeth / Woo, Ellen / Rogalski, Emily / Lethbridge, Emma / Dooley, Eoin / Artiges, Eric / Foster, Eric / Reiman, Eric M / Quinlan, Erin Burke / Franklin, Erin / Heinzen, Erin L / Fletcher, Evan / Sprenger, Fabienne / Crivello, Fabrice / Biondo, Francesca / Parfitt, Francine / Hefti, Franz / Beyer, Frauke / Nees, Frauke / Pike, G Bruce / Leonard, Gabriel / Robert, Gabriel / Thai, Gaby / Marshall, Gad A / Barker, Gareth / Conrad, Gary / Roshchupkin, Gennady V / Tremont, Geoffrey / Bartzokis, George / Hsiung, Ging-Yuek Robin / Malferrari, Giulia / Chiang, Gloria / Pearlson, Godfrey D / Liang, Grace / Jicha, Greg / Sorensen, Greg / Todd, Gretchen / Schumann, Gunter / Jimenez, Gustavo / Zare, Habil / Grabe, Hans Jörgen / Vanderswag, Helen / Schmidt, Helena / Venkov, Heli / Walter, Henrik / Brodaty, Henry / Flor, Herta / Lemaitre, Hervé / Adams, Hieab H H / Grossman, Hillel / Shill, Holly / Soares, Holly / Lin, Honghuang / Capote, Horacio / Bergman, Howard / Chertkow, Howard / Feldman, Howard / Fillit, Howard / Rosen, Howard J / Koleva, Hristina / Fernandez, Hubert / Garavan, Hugh / Shim, Hyungsub / Deary, Ian J / Grachev, Igor D / Richard, Irene / Filippi, Irina / Rachinsky, Irina / Wurster, Isabel / Mintzer, Jacobo / Ziolkowski, Jaimie / Brewer, James / Lah, James J / Leverenz, James / Becker, James T / Tetrud, James / Singleton-Garvin, Jamika / Egebjerg, Jan / Cellar, Janet S / Pentilla, Jani / Brosch, Jared R / Tinklenberg, Jared / Karlawish, Jason H / Meyer, Javier Villanueva / Himali, Jayandra J / Poline, Jean-Baptiste / Martinot, Jean-Luc / Gunter, Jeff / Kaye, Jeffrey A / Dalley, Jeffrey / Burns, Jeffrey M / Petrella, Jeffrey R / Mule, Jennifer / Salazar, Jennifer / Rotter, Jerome I / Yesavage, Jerome / Cedarbaum, Jesse / Jiang, Jiyang / Wardlaw, Joanna M / Allard, Joanne / Lord, Joanne L / Hetelle, Joel / Kwok, John B / Brockington, John / Morris, John C / Hsiao, John / Morris, John / Olichney, John / Trojanowki, John Q / Rogers, John / Seibyl, John / Yankey, Jon / Dubow, Jordan S / Jankovic, Joseph / Quinn, Joseph / Kass, Joseph S / Bis, Joshua C / Taylor, Joy L / Heidebrink, Judith L / Trollor, Julian / Fröhner, Juliane / Mather, Karen A / Anderson, Karen / Blank, Karen / Crawford, Karen / Smith, Karen Ekstam / Bell, Karen L / Williams, Karen / Kieburtz, Karl / Gauss, Katharina / Wittfeld, Katharina / Gloer, Katherine / Johnson, Kathleen / Tingus, Kathleen / DeMarco, Kathryn / Sink, Kaycee M / Hawkins, Keith A / Johnson, Keith A / Kantarci, Kejal / Faber, Kelley / Harless, Kelly / Makino, Kelly M / Marek, Kenneth / Spicer, Kenneth / Shianna, Kevin / Chen, Kewei / Nam, Ki Won / Martin, Kim / Poki-Walker, Kim / Seppi, Klaus / Johnson, Kris / Fargher, Kristin / Lipowski, Kristine / Espay, Kristy / Nho, Kwangsik / Womack, Kyle / Chahine, Lama / Flashman, Laura A / Daedelow, Laura / Leary, Laura / Beckett, Laurel / Honig, Lawrence S / Thal, Leon / Shaw, Leslie M / Kuller, Lew / Shen, Li / Apostolova, Liana / Teodoro, Liberty / Rees, Linda / Lewis, Lindsay / Hergesheimer, Lindsey / Silbert, Lisa C / Ravdin, Lisa / Taylor-Reinwald, Lisa / Uribe, Liz / Schneider, Lon S / Daiello, Lori A / Richer, Louis / Poustka, Luise / Pirpamer, Lukas / Ikram, M Arfan / Mesulam, M Marcel / Ismail, M Saleem / Ranola, Madelaine / Korecka, Magdalena / Bernard, Manon / Raichle, Marc / Seltzer, Marc / van der Brug, Marcel / 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/ Chowdhury, Munir / Fornage, Myriam / Trncic, Nadira / Amin, Najaf / Johnson, Nancy / Kowalksi, Nancy / Monahan, Nancy / Gillespie, Nathan A / Pacini, Nathaniel / Buckholtz, Neil / Kowall, Neil / Graff-Radford, Neill R / Fox, Nick / Armstrong, Nicola J / Pavese, Nicola / Cairns, Nigel J / Schuff, Norbert / Foster, Norm / Relkin, Norman / Oyonumo, Ntekim E / Pomara, Nunzio / Andreassen, Ole A / James, Olga / Ogunlana, Olu / Lopez, Oscar L / Carmichael, Owen / Doraiswamy, P Murali / Casalin, Paola / Barone, Paolo / Fatica, Parianne / Conrod, Patricia / Johnson, Patricia Lynn / Samuels, Patricia / Aisen, Paul / Malloy, Paul / Thompson, Paul / Ogrocki, Paula / Bezivin-Frere, Pauline / Maillard, Pauline / Fontoura, Paulo / Taylor, Peggy / Hogarth, Penelope / Gowland, Penny / Sachdev, Perminder S / Davies, Peter / Hardy, Peter / Snyder, Peter J / Schofield, Peter R / Snyder, Peter / Amouyel, Philippe / Muglia, Pierandrea / Tariot, Pierre / Lu, Po H / Varma, Pradeep / Vemuri, Prashanthi / Yang, Qiong / Doody, Rachelle S / Carter, Raina / Shah, Raj C / Griffith, Randall / Yeh, Randy / Duara, Ranjan / Tarawneh, Rawan / James, Raymond / Turner, Raymond Scott / Hernando, Raymundo / Silverstein, Rebecca / Schmidt, Reinhold / Sperling, Reisa A / Wilson, Renee / Carson, Richard E / Frank, Richard / El Khouli, Riham / Koeppe, Robert A / Santulli, Robert B / Green, Robert C / Hauser, Robert / Umek, Robert / Whelan, Robert / Bülow, Robin / Radtke, Rodney / Killiany, Ronald / Petersen, Ronald / Rodriguez, Rosemarie / Miranda, Ruben / Bruehl, Ruediger / Xia, Rui / Swerdlow, Russell H / Ottmann, Ruth / Millenet, Sabina / Borges-Neto, Salvador / Frank, Samuel / Black, Sandra / Weintraub, Sandra / Obradov, Sanja / Asthana, Sanjay / Vaishnavi, Sanjeev / Dolen, Sara / Mason, Sara S / Hohmann, Sarah / Kremen, Sarah / Miller, Sarah / Walter, Sarah / Herring, Scott / Neu, Scott / Aydin, Semiha / Ahmad, Shahzad / Karama, Sherif / Harlan, Sherry / Sirrel, Sherye A / Lasch, Shirley / Hu, Shu-Ching / Li, Shuo / Kittur, Smita / Chowdhury, Sohini / Pawluczyk, Sonia / Maingault, Sophie / Schneider, Stacy / Seiler, Stephan / Debette, Stephanie / Guthrie, Stephanie / Kielb, Stephanie / Reeder, Stephanie / Correia, Stephen / Pasternak, Stephen / Salloway, Stephen / Johnson, Sterling / Williams, Steve / Chao, Steven / Arnold, Steven E / Paul, Steven / Potkin, Steven / Factor, Stewart / Isaacson, Stuart / Seshadri, Sudha / Kim, Sungeun / Ainscough, Susan / Schultz, Susan K / Landau, Susan / Mendick, Susan / Rountree, Susan / Ostrowizki, Suzanne / Veillette, Suzanne / van der Lee, Sven J / Desrivieres, Sylvane / Lee, T-Y / Simuni, Tanya / Foroud, Tatiana / Foroud, Tatiana M / Wong, Terence Z / Villena, Teresa / Comery, Thomas / Mosley, Thomas H / Obisesan, Thomas O / Jia, Tianye / Banaschewski, Tobias / Sherer, Todd / Montine, Tom / Paus, Tomáš / Robbins, Trevor / Bromberg, Uli / Völker, Uwe / Pavlik, Valory / Arnedo, Vanessa / Kiyasova, Vera / Bates, Vernice / Logovinsky, Veronika / Sossi, Vesna / Shibley, Victoria / Frouin, Vincent / Lee, Virginia / Wen, Wei / Poewe, Werner / Jagust, William / Brooks, William M / Pavlosky, William / Potter, William / Kremen, William S / Longstreth, William T / Niessen, Wiro J / Jian, Xueqiu / Stern, Yaakov / Saba, Yasaman / Cabrera, Yuliana / Grimmer, Yvonne / Khachaturian, Zaven / Pausova, Zdenka / Mari, Zoltan
Strukturelle und funktionelle Organisation des Gehirns; INM-1
Science / Science now Science now, 367 (2020) 6484, S. 1340
Washington, DC Assoc.73085 2020
10.1126/science.aay6690
32193296
Journal Article
Human Brain Project Specific Grant Agreement 2
Human Brain Project Specific Grant Agreement 1
Connectivity and Activity
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Please use the identifier: http://dx.doi.org/10.1126/science.aay6690 in citations.
Please use the identifier: http://hdl.handle.net/2128/25415 in citations.
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.