This title appears in the Scientific Report :
2020
Please use the identifier:
http://dx.doi.org/10.1007/s11307-020-01503-x in citations.
Please use the identifier: http://hdl.handle.net/2128/25767 in citations.
Investigation of Cerebral O-(2-[$^{18}$F]Fluoroethyl)-L-Tyrosine Uptake in Rat Epilepsy Models
Investigation of Cerebral O-(2-[$^{18}$F]Fluoroethyl)-L-Tyrosine Uptake in Rat Epilepsy Models
A recent study reported on high, longer lasting and finally reversible cerebral uptake of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) induced by epileptic activity. Therefore, we examined cerebral [18F]FET uptake in two chemically induced rat epilepsy models and in patients with focal epilepsy to f...
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Personal Name(s): | Stegmayr, Carina (Corresponding author) |
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Surges, Rainer / Choi, Chang-Hoon / Burda, Nicole / Stoffels, Gabriele / Filß, Christian / Willuweit, Antje / Neumaier, Bernd / Heinzel, Alexander / Shah, N. Jon / Mottaghy, Felix M. / Langen, Karl-Josef | |
Contributing Institute: |
Jara-Institut Quantum Information; INM-11 JARA-BRAIN; JARA-BRAIN Nuklearchemie; INM-5 Physik der Medizinischen Bildgebung; INM-4 |
Published in: | Molecular imaging & biology, 22 (2020) S. 1255–1265 |
Imprint: |
New York [u.a.]
Springer
2020
|
PubMed ID: |
32409931 |
DOI: |
10.1007/s11307-020-01503-x |
Document Type: |
Journal Article |
Research Program: |
Neuroimaging |
Link: |
OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/25767 in citations.
A recent study reported on high, longer lasting and finally reversible cerebral uptake of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) induced by epileptic activity. Therefore, we examined cerebral [18F]FET uptake in two chemically induced rat epilepsy models and in patients with focal epilepsy to further investigate whether this phenomenon represents a major pitfall in brain tumor diagnostics and whether [18F]FET may be a potential marker to localize epileptic foci.Five rats underwent kainic acid titration to exhibit 3 to 3.5 h of class IV–V motor seizures (status epilepticus, SE). Rats underwent 4× [18F]FET PET and 4× MRI on the following 25 days. Six rats underwent kindling with pentylenetetrazol (PTZ) 3 to 8×/week over 10 weeks, and hence, seizures increased from class I to class IV. [18F]FET PET and MRI were performed regularly on days with and without seizures. Four rats served as healthy controls. Additionally, five patients with focal epilepsy underwent [18F]FET PET within 12 days after the last documented seizure.No abnormalities in [18F]FET PET or MRI were detected in the kindling model. The SE model showed significantly decreased [18F]FET uptake 3 days after SE in all examined brain regions, and especially in the amygdala region, which normalized within 2 weeks. Corresponding signal alterations in T2-weighted MRI were noted in the amygdala and hippocampus, which recovered 24 days post-SE. No abnormality of cerebral [18F]FET uptake was noted in the epilepsy patients.There was no evidence for increased cerebral [18F]FET uptake after epileptic seizures neither in the rat models nor in patients. The SE model even showed decreased [18F]FET uptake throughout the brain. We conclude that epileptic seizures per se do not cause a longer lasting increased [18F]FET accumulation and are unlikely to be a major cause of pitfall for brain tumor diagnostics. |