This title appears in the Scientific Report :
2021
Please use the identifier:
http://dx.doi.org/10.1007/s11940-021-00664-6 in citations.
Please use the identifier: http://hdl.handle.net/2128/27129 in citations.
Imaging of response to radiosurgery and immunotherapy in brain metastses: Quo vadis?
Imaging of response to radiosurgery and immunotherapy in brain metastses: Quo vadis?
Purpose of ReviewThis review presents an overview of how advanced imaging techniques may help to overcome shortcomings of anatomical MRI for response assessment in patients with brain metastases who are undergoing stereotactic radiosurgery, immunotherapy, or combinations thereof.Recent FindingsStudy...
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Personal Name(s): | Galldiks, Norbert (Corresponding author) |
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Jan-Michael, Werner / Lohmann, Philipp / Kocher, Martin / Fink, Gereon Rudolf / Langen, Karl-Josef | |
Contributing Institute: |
Physik der Medizinischen Bildgebung; INM-4 Kognitive Neurowissenschaften; INM-3 |
Published in: | Current treatment options in neurology, 23 (2021) 3, S. 7 |
Imprint: |
Philadelphia, Pa.
Current Science Inc.
2021
|
DOI: |
10.1007/s11940-021-00664-6 |
Document Type: |
Journal Article |
Research Program: |
Decoding Brain Organization and Dysfunction |
Link: |
OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/27129 in citations.
Purpose of ReviewThis review presents an overview of how advanced imaging techniques may help to overcome shortcomings of anatomical MRI for response assessment in patients with brain metastases who are undergoing stereotactic radiosurgery, immunotherapy, or combinations thereof.Recent FindingsStudy results suggest that parameters derived from amino acid PET, diffusion- and perfusion-weighted MRI, MR spectroscopy, and newer MRI methods are particularly helpful for the evaluation of the response to radiosurgery or checkpoint inhibitor immunotherapy and provide valuable information for the differentiation of radiotherapy-induced changes such as radiation necrosis from brain metastases. The evaluation of these imaging modalities is also of great interest in the light of emerging high-throughput analysis methods such as radiomics, which allow the acquisition of additional data at a low cost.SummaryPreliminary results are promising and should be further evaluated. Shortcomings are different levels of PET and MRI standardization, the number of patients enrolled in studies, and the monocentric and retrospective character of most studies. |