This title appears in the Scientific Report :
2020
Please use the identifier:
http://dx.doi.org/10.1002/hbm.25101 in citations.
Please use the identifier: http://hdl.handle.net/2128/26448 in citations.
Invasive versus non‐invasive mapping of the motor cortex
Invasive versus non‐invasive mapping of the motor cortex
Precise and comprehensive mapping of somatotopic representations in the motor cortex is clinically essential to achieve maximum resection of brain tumours whilst preserving motor function, especially since the current gold standard, that is, intraoperative direct cortical stimulation (DCS), holds li...
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Personal Name(s): | Weiss Lucas, Carolin (Corresponding author) |
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Nettekoven, Charlotte / Neuschmelting, Volker / Oros‐Peusquens, Ana‐Maria / Stoffels, Gabriele / Viswanathan, Shivakumar / Rehme, Anne K. / Faymonville, Andrea Maria / Shah, N. Jon / Langen, Karl Josef / Goldbrunner, Roland / Grefkes, Christian | |
Contributing Institute: |
Physik der Medizinischen Bildgebung; INM-4 Kognitive Neurowissenschaften; INM-3 |
Published in: | Human brain mapping, 41 (2020) 14, S. 3970 - 3983 |
Imprint: |
New York, NY
Wiley-Liss
2020
|
PubMed ID: |
32588936 |
DOI: |
10.1002/hbm.25101 |
Document Type: |
Journal Article |
Research Program: |
(Dys-)function and Plasticity |
Link: |
OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/26448 in citations.
Precise and comprehensive mapping of somatotopic representations in the motor cortex is clinically essential to achieve maximum resection of brain tumours whilst preserving motor function, especially since the current gold standard, that is, intraoperative direct cortical stimulation (DCS), holds limitations linked to the intraoperative setting such as time constraints or anatomical restrictions. Non‐invasive techniques are increasingly relevant with regard to pre‐operative risk‐assessment. Here, we assessed the congruency of neuronavigated transcranial magnetic stimulation (nTMS) and functional magnetic resonance imaging (fMRI) with DCS. The motor representations of the hand, the foot and the tongue regions of 36 patients with intracranial tumours were mapped pre‐operatively using nTMS and fMRI and by intraoperative DCS. Euclidean distances (ED) between hotspots/centres of gravity and (relative) overlaps of the maps were compared. We found significantly smaller EDs (11.4 ± 8.3 vs. 16.8 ± 7.0 mm) and better spatial overlaps (64 ± 38% vs. 37 ± 37%) between DCS and nTMS compared with DCS and fMRI. In contrast to DCS, fMRI and nTMS mappings were feasible for all regions and patients without complications. In summary, nTMS seems to be the more promising non‐invasive motor cortex mapping technique to approximate the gold standard DCS results. |