This title appears in the Scientific Report :
2020
Please use the identifier:
http://dx.doi.org/10.1088/1742-5468/ab7a1d in citations.
On the stationary frequency of programmed ribosomal −1 frameshift
On the stationary frequency of programmed ribosomal −1 frameshift
We present a stochastic model for programmed ribosomal −1 frameshift, triggered by a slippery sequence and a following pseudoknot on the mRNA template, that allows for the exact derivation of the stationary distribution of ribosome positions and for exact analytical calculations of the stationary ra...
| Personal Name(s): | Schütz, Gunter M. (Corresponding author) |
|---|---|
| Contributing Institute: |
Theoretische Physik der Lebenden Materie; IBI-5 |
| Published in: | Journal of statistical mechanics: theory and experiment, 2020 (2020) 4, S. 043502 |
| Imprint: |
Bristol
IOP Publ.
2020
|
| DOI: |
10.1088/1742-5468/ab7a1d |
| Document Type: |
Journal Article |
| Research Program: |
Physical Basis of Diseases |
| Publikationsportal JuSER |
|
We present a stochastic model for programmed ribosomal −1 frameshift, triggered by a slippery sequence and a following pseudoknot on the mRNA template, that allows for the exact derivation of the stationary distribution of ribosome positions and for exact analytical calculations of the stationary rate of frameshift, its efficiency and other quantities of interest. We also present the stationary phase diagram as a function of the initiation rate and the density ribosomes that the pseudoknot can support. These observations provide mathematically rigorous evidence for the notion that the density of molecular motors is an important control parameter for the elongation rate in the presence of slippery sequences both in transcription of RNA and translation of proteins. |