This title appears in the Scientific Report :
2021
Please use the identifier:
http://dx.doi.org/10.1103/PhysRevLett.126.088102 in citations.
Please use the identifier: http://hdl.handle.net/2128/28019 in citations.
Diffusivelike Motions in a Solvent-Free Protein-Polymer Hybrid
Diffusivelike Motions in a Solvent-Free Protein-Polymer Hybrid
The interaction between proteins and hydration water stabilizes protein structure and promotes functional dynamics, with water translational motions enabling protein flexibility. Engineered solvent-free protein-polymer hybrids have been shown to preserve protein structure, function, and dynamics. He...
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Personal Name(s): | Schirò, Giorgio (Corresponding author) |
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Fichou, Yann (Corresponding author) / Brogan, Alex P. S. / Sessions, Richard / Lohstroh, Wiebke / Zamponi, Michaela / Schneider, Gerald J. / Gallat, François-Xavier / Paciaroni, Alessandro / Tobias, Douglas J. / Perriman, Adam / Weik, Martin (Corresponding author) | |
Contributing Institute: |
JCNS-FRM-II; JCNS-FRM-II Heinz Maier-Leibnitz Zentrum; MLZ JCNS-4; JCNS-4 Neutronenstreuung; JCNS-1 |
Published in: | Physical review letters, 126 (2021) 8, S. 088102 |
Imprint: |
College Park, Md.
APS
2021
|
DOI: |
10.1103/PhysRevLett.126.088102 |
Document Type: |
Journal Article |
Research Program: |
Materials – Quantum, Complex and Functional Materials Jülich Centre for Neutron Research (JCNS) (FZJ) |
Subject (ZB): | |
Link: |
OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/28019 in citations.
The interaction between proteins and hydration water stabilizes protein structure and promotes functional dynamics, with water translational motions enabling protein flexibility. Engineered solvent-free protein-polymer hybrids have been shown to preserve protein structure, function, and dynamics. Here, we used neutron scattering, protein and polymer perdeuteration, and molecular dynamics simulations to explore how a polymer dynamically replaces water. Even though relaxation rates and vibrational properties are strongly modified in polymer coated compared to hydrated proteins, liquidlike polymer dynamics appear to plasticize the conjugated protein in a qualitatively similar way as do hydration-water translational motions. |