This title appears in the Scientific Report :
2021
Please use the identifier:
http://dx.doi.org/10.1039/D1CC00745A in citations.
Please use the identifier: http://hdl.handle.net/2128/27898 in citations.
Rapid 18 F-labeling via Pd-catalyzed S -arylation in aqueous medium
Rapid 18 F-labeling via Pd-catalyzed S -arylation in aqueous medium
We report radiolabeling of thiol-containing substrates via Pd-catalyzed S-arylation with 2-[18F]fluoro-5-iodopyridine, which is readily accessible using the “minimalist” radiofluorination method. The practicality of the procedure was confirmed by preparation of a novel PSMA-specific PET-tracer as we...
| Personal Name(s): | Humpert, Swen |
|---|---|
| Omrane, Mohamed A. / Urusova, Elizaveta / Gremer, Lothar / Willbold, Dieter / Endepols, Heike / Krasikova, Raisa N. / Neumaier, Bernd (Corresponding author) / Zlatopolskiy, Boris D. | |
| Contributing Institute: |
Strukturbiochemie; IBI-7 Nuklearchemie; INM-5 |
| Published in: | Chemical communications, 57 (2021) S. 3547-3550 |
| Imprint: |
Cambridge
Soc.
2021
|
| DOI: |
10.1039/D1CC00745A |
| Document Type: |
Journal Article |
| Research Program: |
Decoding Brain Organization and Dysfunction |
| Link: |
OpenAccess |
| Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/27898 in citations.
|
We report radiolabeling of thiol-containing substrates via Pd-catalyzed S-arylation with 2-[18F]fluoro-5-iodopyridine, which is readily accessible using the “minimalist” radiofluorination method. The practicality of the procedure was confirmed by preparation of a novel PSMA-specific PET-tracer as well as labeling of glutathione, Aβ oligomer-binding RD2 peptide, bovine serum albumin and PSMA I&S. |