This title appears in the Scientific Report :
2021
Please use the identifier:
http://hdl.handle.net/2128/27735 in citations.
Please use the identifier: http://dx.doi.org/10.1016/j.neulet.2021.135811 in citations.
An analysis of the CatWalk XT and a composite score to assess neurofunctional deficits after photothrombosis in mice
An analysis of the CatWalk XT and a composite score to assess neurofunctional deficits after photothrombosis in mice
The purpose of this study was to evaluate CatWalk’s capability for assessing the functional outcome after photothrombotic stroke affecting the motor cortex of mice. Mice were tested up to 21 days after photothrombosis or sham surgery using CatWalk, and a composite score assessing functional deficits...
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Personal Name(s): | Bärmann, J. |
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Walter, H. L. / Pikhovych, A. / Endepols, H. / Fink, G. R. / Rueger, M. A. / Schroeter, M. (Corresponding author) | |
Contributing Institute: |
Nuklearchemie; INM-5 Kognitive Neurowissenschaften; INM-3 |
Published in: | Neuroscience letters, 751 (2021) S. 135811 - |
Imprint: |
Amsterdam [u.a.]
Elsevier Science
2021
|
DOI: |
10.1016/j.neulet.2021.135811 |
Document Type: |
Journal Article |
Research Program: |
Decoding Brain Organization and Dysfunction |
Link: |
OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1016/j.neulet.2021.135811 in citations.
The purpose of this study was to evaluate CatWalk’s capability for assessing the functional outcome after photothrombotic stroke affecting the motor cortex of mice. Mice were tested up to 21 days after photothrombosis or sham surgery using CatWalk, and a composite score assessing functional deficits (neuroscore).The neuroscore demonstrated deficits of the contralateral forelimb for more than two weeks after stroke. There were no asymmetric or coordinative dysfunctions of limbs detected by CatWalk. However, CatWalk data revealed impairment of locomotion speed and its depending parameters for one-week after stroke in strong correlation to the neuroscore.Data suggest that the composite neuroscore allows to more sensitively and precisely specify and quantify photothrombosis-induced hemisyndromes than CatWalk. |