This title appears in the Scientific Report :
2021
Please use the identifier:
http://dx.doi.org/10.3390/cancers13102373 in citations.
Please use the identifier: http://hdl.handle.net/2128/27800 in citations.
Lesion-Function Analysis from Multimodal Imaging and Normative Brain Atlases for Prediction of Cognitive Deficits in Glioma Patients
Lesion-Function Analysis from Multimodal Imaging and Normative Brain Atlases for Prediction of Cognitive Deficits in Glioma Patients
Cognitive deficits are common in glioma patients following multimodality therapy, but the relative impact of different types and locations of treatment-related brain damage and recurrent tumors on cognition is not well understood. In 121 WHO Grade III/IV glioma patients, structural MRI, O-(2-[18F]fl...
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Personal Name(s): | Kocher, Martin (Corresponding author) |
---|---|
Jockwitz, Christiane / Lohmann, Philipp / Stoffels, Gabriele / Filss, Christian / Mottaghy, Felix M. / Ruge, Maximilian I. / Weiss Lucas, Carolin / Goldbrunner, Roland / Shah, N. J. / Fink, Gereon R. / Galldiks, Norbert / Langen, Karl-Josef / Caspers, Svenja | |
Contributing Institute: |
Physik der Medizinischen Bildgebung; INM-4 Jülich-Aachen Research Alliance - Translational Brain Medicine; JARA-BRAIN Kognitive Neurowissenschaften; INM-3 Strukturelle und funktionelle Organisation des Gehirns; INM-1 Jara-Institut Quantum Information; INM-11 |
Published in: | Cancers, 13 (2021) 10, S. 2373 - |
Imprint: |
Basel
MDPI
2021
|
DOI: |
10.3390/cancers13102373 |
Document Type: |
Journal Article |
Research Program: |
Human Brain Project Specific Grant Agreement 3 Decoding Brain Organization and Dysfunction |
Link: |
OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/27800 in citations.
Cognitive deficits are common in glioma patients following multimodality therapy, but the relative impact of different types and locations of treatment-related brain damage and recurrent tumors on cognition is not well understood. In 121 WHO Grade III/IV glioma patients, structural MRI, O-(2-[18F]fluoroethyl)-L-tyrosine FET-PET, and neuropsychological testing were performed at a median interval of 14 months (range, 1–214 months) after therapy initiation. Resection cavities, T1-enhancing lesions, T2/FLAIR hyperintensities, and FET-PET positive tumor sites were semi-automatically segmented and elastically registered to a normative, resting state (RS) fMRI-based functional cortical network atlas and to the JHU atlas of white matter (WM) tracts, and their influence on cognitive test scores relative to a cohort of matched healthy subjects was assessed. T2/FLAIR hyperintensities presumably caused by radiation therapy covered more extensive brain areas than the other lesion types and significantly impaired cognitive performance in many domains when affecting left-hemispheric RS-nodes and WM-tracts as opposed to brain tissue damage caused by resection or recurrent tumors. Verbal episodic memory proved to be especially vulnerable to T2/FLAIR abnormalities affecting the nodes and tracts of the left temporal lobe. In order to improve radiotherapy planning, publicly available brain atlases, in conjunction with elastic registration techniques, should be used, similar to neuronavigation in neurosurgery. |