This title appears in the Scientific Report :
2021
Please use the identifier:
http://hdl.handle.net/2128/29099 in citations.
Please use the identifier: http://dx.doi.org/10.1002/anie.202103406 in citations.
Lewis Base–Brønsted Acid–Enzyme Catalysis in Enantioselective Multistep One‐Pot Syntheses
Lewis Base–Brønsted Acid–Enzyme Catalysis in Enantioselective Multistep One‐Pot Syntheses
Establishing one-pot, multi-step protocols combining different types of catalysts is one important goal for increasing efficiency in modern organic synthesis. In particular, the high potential of biocatalysts still needs to be harvested. Based on an in-depth mechanistic investigation of a new organo...
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Personal Name(s): | Mantel, Marvin |
---|---|
Giesler, Markus / Guder, Marian / Rüthlein, Elisabeth / Hartmann, Laura / Pietruszka, Jörg (Corresponding author) | |
Contributing Institute: |
Biotechnologie; IBG-1 Institut für Bioorganische Chemie (HHUD); IBOC |
Published in: | Angewandte Chemie / International edition, 60 (2021) 30, S. 16700 - 16706 |
Imprint: |
Weinheim
Wiley-VCH
2021
|
PubMed ID: |
33856095 |
DOI: |
10.1002/anie.202103406 |
Document Type: |
Journal Article |
Research Program: |
Biological and environmental resources for sustainable use |
Link: |
OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1002/anie.202103406 in citations.
Establishing one-pot, multi-step protocols combining different types of catalysts is one important goal for increasing efficiency in modern organic synthesis. In particular, the high potential of biocatalysts still needs to be harvested. Based on an in-depth mechanistic investigation of a new organocatalytic protocol employing two catalysts {1,4-diazabicyclo[2.2.2]octane (DABCO); benzoic acid (BzOH)}, a sequence was established providing starting materials for enzymatic refinement (ene reductase; alcohol dehydrogenase): A gram-scale access to a variety of enantiopure key building blocks for natural product syntheses was enabled utilizing up to six catalytic steps within the same reaction vessel. |