This title appears in the Scientific Report :
2021
Please use the identifier:
http://dx.doi.org/10.1016/j.tins.2021.10.003 in citations.
Please use the identifier: http://hdl.handle.net/2128/29189 in citations.
The many dimensions of human hippocampal organization and (dys)function
The many dimensions of human hippocampal organization and (dys)function
Magnetic resonance imaging–based parcellation of the hippocampal formation and gradient mapping are data-driven techniques that can capture many dimensions of hippocampal organization and provide readily usable outcomes. Features of cortical architecture, such as local connectivity and microstruc...
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Personal Name(s): | Genon, Sarah (Corresponding author) |
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Bernhardt, Boris C. / La Joie, Renaud / Amunts, Katrin / Eickhoff, Simon B. | |
Contributing Institute: |
Strukturelle und funktionelle Organisation des Gehirns; INM-1 Gehirn & Verhalten; INM-7 |
Published in: | Trends in neurosciences, 44 (2021) 12, S. 977-989 |
Imprint: |
Amsterdam [u.a.]
Elsevier Science
2021
|
DOI: |
10.1016/j.tins.2021.10.003 |
PubMed ID: |
34756460 |
Document Type: |
Journal Article |
Research Program: |
Human Brain Project Specific Grant Agreement 2 Human Brain Project Specific Grant Agreement 3 JL SMHB - Joint Lab Supercomputing and Modeling for the Human Brain (JL SMHB-2021-2027) Multilevel Brain Organization and Variability |
Link: |
Get full text OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/29189 in citations.
Magnetic resonance imaging–based parcellation of the hippocampal formation and gradient mapping are data-driven techniques that can capture many dimensions of hippocampal organization and provide readily usable outcomes. Features of cortical architecture, such as local connectivity and microstructure, reveal differentiation within the hippocampal formation along the medial–lateral axis. This organizational dimension seemingly reflects local information-processing organization. Neuroimaging markers tapping into hippocampal integration into large-scale networks (i.e., whole-brain connectivity) highlight the long-axis differentiation. The long-axis organization corresponds to a molecular gradient and differential integration across distinct behavioral systems. Capitalizing on gradients and parcellations maps, the long-axis organization of the hippocampal formation can be related to behavioral phenotypes in healthy and clinical populations. |