This title appears in the Scientific Report :
2021
Please use the identifier:
http://hdl.handle.net/2128/30299 in citations.
Please use the identifier: http://dx.doi.org/10.1007/s12028-021-01250-z in citations.
Isoflurane in (Super-) Refractory Status Epilepticus: A Multicenter Evaluation
Isoflurane in (Super-) Refractory Status Epilepticus: A Multicenter Evaluation
AbstractBackground: We aimed to determine the association between seizure termination and side effects of isoflurane forthe treatment of refractory status epilepticus (RSE) and super-refractory status epilepticus (SRSE) in neurointensivecare units (neuro-ICUs).Methods: This was a multicenter retrosp...
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Personal Name(s): | Stetefeld, Henning R. |
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Schaal, Alexander / Scheibe, Franziska / Nichtweiß, Julia / Lehmann, Felix / Müller, Marcus / Gerner, Stefan T. / Huttner, Hagen B. / Luger, Sebastian / Fuhrer, Hannah / Bösel, Julian / Schönenberger, Silvia / Dimitriadis, Konstantinos / Neumann, Bernhard / Fuchs, Kornelius / Fink, Gereon R. / Malter, Michael P. (Corresponding author) | |
Contributing Institute: |
Kognitive Neurowissenschaften; INM-3 |
Published in: | Neurocritical care, 35 (2021) 3, S. 631 - 639 |
Imprint: |
New York, NY
Springer
2021
|
PubMed ID: |
34286464 |
DOI: |
10.1007/s12028-021-01250-z |
Document Type: |
Journal Article |
Research Program: |
Brain Dysfunction and Plasticity |
Link: |
OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1007/s12028-021-01250-z in citations.
AbstractBackground: We aimed to determine the association between seizure termination and side effects of isoflurane forthe treatment of refractory status epilepticus (RSE) and super-refractory status epilepticus (SRSE) in neurointensivecare units (neuro-ICUs).Methods: This was a multicenter retrospective study of patients with RSE/SRSE treated with isoflurane for statusepilepticus termination admitted to the neuro-ICUs of nine German university centers during 2011–2018.Results: We identified 45 patients who received isoflurane for the treatment of RSE/SRSE. During isoflurane treat-ment, electroencephalograms showed no epileptiform discharges in 33 of 41 (80%) patients, and burst suppressionpattern was achieved in 29 of 41 patients (71%). RSE/SRSE was finally terminated after treatment with isoflurane in 23of 45 patients (51%) for the entire group and in 13 of 45 patients (29%) without additional therapy. Lengths of stay inthe hospital and in the neuro-ICU were significantly extended in cases of ongoing status epilepticus under isofluranetreatment (p = 0.01 for length of stay in the hospital, p = 0.049 for length in the neuro-ICU). During isoflurane treat-ment, side effects were reported in 40 of 45 patients (89%) and mainly included hypotension (n = 40, 89%) and/orinfection (n = 20, 44%). Whether side effects occurred did not affect the outcome at discharge. Of 22 patients withfollow-up magnetic resonance imaging, 2 patients (9%) showed progressive magnetic resonance imaging alterationsthat were considered to be potentially associated with RSE/SRSE itself or with isoflurane therapy.Conclusions: Isoflurane was associated with a good effect in stopping RSE/SRSE. Nevertheless, establishing remis-sion remained difficult. Side effects were common but without effect on the outcome at discharge.Keywords: Status epilepticus, Isoflurane, Epilepsy |