This title appears in the Scientific Report :
2021
Please use the identifier:
http://dx.doi.org/10.3390/jcm10071454 in citations.
Please use the identifier: http://hdl.handle.net/2128/30230 in citations.
Replication of Previous Findings? Comparing Gray Matter Volumes in Transgender Individuals with Gender Incongruence and Cisgender Individuals
Replication of Previous Findings? Comparing Gray Matter Volumes in Transgender Individuals with Gender Incongruence and Cisgender Individuals
The brain structural changes related to gender incongruence (GI) are still poorly understood. Previous studies comparing gray matter volumes (GMV) between cisgender and transgender individuals with GI revealed conflicting results. Leveraging a comprehensive sample of transmen (n = 33), transwomen (n...
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Personal Name(s): | Clemens, Benjamin (Corresponding author) |
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Votinov, Mikhail / Puiu, Andrei Alexandru / Schüppen, Andre / Hüpen, Philippa / Neulen, Josef / Derntl, Birgit / Habel, Ute | |
Contributing Institute: |
Jara-Institut Brain structure-function relationships; INM-10 |
Published in: | Journal of Clinical Medicine, 10 (2021) 7, S. 1454 - |
Imprint: |
Basel
MDPI
2021
|
PubMed ID: |
33916288 |
DOI: |
10.3390/jcm10071454 |
Document Type: |
Journal Article |
Research Program: |
Brain Dysfunction and Plasticity |
Link: |
OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/30230 in citations.
The brain structural changes related to gender incongruence (GI) are still poorly understood. Previous studies comparing gray matter volumes (GMV) between cisgender and transgender individuals with GI revealed conflicting results. Leveraging a comprehensive sample of transmen (n = 33), transwomen (n = 33), cismen (n = 24), and ciswomen (n = 25), we employ a region-of-interest (ROI) approach to examine the most frequently reported brain regions showing GMV differences between trans- and cisgender individuals. The primary aim is to replicate previous findings and identify anatomical regions which differ between transgender individuals with GI and cisgender individuals. On the basis of a comprehensive literature search, we selected a set of ROIs (thalamus, putamen, cerebellum, angular gyrus, precentral gyrus) for which differences between cis- and transgender groups have been previously observed. The putamen was the only region showing significant GMV differences between cis- and transgender, across previous studies and the present study. We observed increased GMV in the putamen for transwomen compared to both transmen and ciswomen and for all transgender participants compared to all cisgender participants. Such a pattern of neuroanatomical differences corroborates the large majority of previous studies. This potential replication of previous findings and the known involvement of the putamen in cognitive processes related to body representations and the creation of the own body image indicate the relevance of this region for GI and its potential as a structural biomarker for GI |