Description: Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex

This title appears in the Scientific Report : 2021

Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex

Brain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral flexibility. However, it remains unclear how a static, genetically controlled architecture supports flexible cognition and behavior. Here, we synthesize genetic, phylogenetic and cognitive analyses to unders...

Personal Name(s):	Valk, Sofie L (Corresponding author)
	Xu, Ting / Paquola, Casey / Park, Bo-yong / Bethlehem, Richard AI / Wael, Reinder Vos de / Royer, Jessica / Masouleh, Shahrzad Kharabian / Bayrak, Şeyma / Kochunov, Peter / Yeo, BT Thomas / Margulies, Daniel / Smallw, Jonathan / Eickhoff, Simon B / Bernhardt, Boris C
Contributing Institute:	Gehirn & Verhalten; INM-7
Imprint:	2021
Document Type:	Preprint
Research Program:	Multilevel Brain Organization and Variability
Link:	OpenAccess
	Publikationsportal JuSER

Please use the identifier: http://hdl.handle.net/2128/30499 in citations.

Brain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral flexibility. However, it remains unclear how a static, genetically controlled architecture supports flexible cognition and behavior. Here, we synthesize genetic, phylogenetic and cognitive analyses to understand how the macroscale organization of structure-function coupling across the cortex can inform its role in cognition. In humans, structure-function coupling was highest in regions of unimodal cortex and lowest in transmodal cortex, a pattern that was mirrored by a reduced alignment with heritable connectivity profiles. Structure-function uncoupling in non-human primates had a similar spatial distribution, but we observed an increased coupling between structure and function in association regions in macaques relative to humans. Meta-analysis suggested regions with the least genetic control (low heritable correspondence and different across primates) are linked to social cognition and autobiographical memory. Our findings establish the genetic and evolutionary uncoupling of structure and function in different transmodal systems may support the emergence of complex, culturally embedded forms of cognition.