This title appears in the Scientific Report :
2022
Please use the identifier:
http://dx.doi.org/10.34734/FZJ-2022-02227 in citations.
Please use the identifier: http://dx.doi.org/10.1038/s41467-022-29886-1 in citations.
Please use the identifier: http://hdl.handle.net/2128/31210 in citations.
Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex
Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex
Brain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral flexibility. However, it remains unclear how a static, genetically controlled architecture supports flexible cognition and behavior. Here, we synthesize genetic, phylogenetic and cognitive analyses to unders...
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Personal Name(s): | Valk, Sofie L. (Corresponding author) |
---|---|
Xu, Ting / Paquola, Casey / Park, Bo-yong / Bethlehem, Richard A. I. / Vos de Wael, Reinder / Royer, Jessica / Masouleh, Shahrzad Kharabian / Bayrak, Şeyma / Kochunov, Peter / Yeo, B. T. Thomas / Margulies, Daniel / Smallwood, Jonathan / Eickhoff, Simon B. / Bernhardt, Boris C. | |
Contributing Institute: |
Gehirn & Verhalten; INM-7 |
Published in: | Nature Communications, 13 (2022) 1, S. 2341 |
Imprint: |
[London]
Nature Publishing Group UK
2022
|
PubMed ID: |
35534454 |
DOI: |
10.34734/FZJ-2022-02227 |
DOI: |
10.1038/s41467-022-29886-1 |
Document Type: |
Journal Article |
Research Program: |
Human Brain Project Specific Grant Agreement 2 Multilevel Brain Organization and Variability |
Link: |
OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1038/s41467-022-29886-1 in citations.
Please use the identifier: http://hdl.handle.net/2128/31210 in citations.
Brain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral flexibility. However, it remains unclear how a static, genetically controlled architecture supports flexible cognition and behavior. Here, we synthesize genetic, phylogenetic and cognitive analyses to understand how the macroscale organization of structure-function coupling across the cortex can inform its role in cognition. In humans, structure-function coupling was highest in regions of unimodal cortex and lowest in transmodal cortex, a pattern that was mirrored by a reduced alignment with heritable connectivity profiles. Structure-function uncoupling in macaques had a similar spatial distribution, but we observed an increased coupling between structure and function in association cortices relative to humans. Meta-analysis suggested regions with the least genetic control (low heritable correspondence and different across primates) are linked to social-cognition and autobiographical memory. Our findings suggest that genetic and evolutionary uncoupling of structure and function in different transmodal systems may support the emergence of complex forms of cognition. |