This title appears in the Scientific Report :
2022
Please use the identifier:
http://hdl.handle.net/2128/31485 in citations.
Please use the identifier: http://dx.doi.org/10.1002/mp.15611 in citations.
Heat management of a compact x‐ray source for microbeam radiotherapy and FLASH treatments
Heat management of a compact x‐ray source for microbeam radiotherapy and FLASH treatments
Background:Microbeam and x-ray FLASH radiation therapy are innovativeconcepts that promise reduced normal tissue toxicity in radiation oncology withoutcompromising tumor control. However, currently only large third-generationsynchrotrons deliver acceptable x-ray beam qualities and there is a need fo...
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Personal Name(s): | Winter, Johanna (Corresponding author) |
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Dimroth, Anton (Corresponding author) / Roetzer, Sebastian / Zhang, Yunzhe / Krämer, Karl-Ludwig / Petrich, Christian / Matejcek, Christoph / Aulenbacher, Kurt / Zimmermann, Markus / Combs, Stephanie E. / Galek, Marek / Natour, Ghaleb / Butzek, Michael / Wilkens, Jan J. / Bartzsch, Stefan | |
Contributing Institute: |
Zentralinstitut für Technologie; ZEA-1 |
Published in: | Medical physics, 49 (2022) 5, S. 3375 - 3388 |
Imprint: |
College Park, Md.
AAPM
2022
|
PubMed ID: |
35315089 |
DOI: |
10.1002/mp.15611 |
Document Type: |
Journal Article |
Research Program: |
Tumortherapie mit Mikrostrahlen an kompakter Strahlenquelle ohne Topic |
Link: |
OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1002/mp.15611 in citations.
Background:Microbeam and x-ray FLASH radiation therapy are innovativeconcepts that promise reduced normal tissue toxicity in radiation oncology withoutcompromising tumor control. However, currently only large third-generationsynchrotrons deliver acceptable x-ray beam qualities and there is a need forcompact, hospital-based radiation sources to facilitate clinical translation ofthese novel treatment strategies.Purpose: We are currently setting up the first prototype of a line-focus x-raytube (LFxT), a promising technology that may deliver ultra-high dose rates(UHDRs) of more than 100 Gy/s from a table-top source. The operation of thesource in the heat capacity limit allows very high dose rates with micrometersizedfocal spot widths.Here,we investigate concepts of effective heat managementfor the LFxT, a prerequisite for the performance of the source.Methods: For different focal spot widths, we investigated the temperatureincrease numerically with Monte Carlo simulations and finite element analysis(FEA).We benchmarked the temperature and thermal stresses at the focal spotagainst a commercial x-ray tube with similar power characteristics.We assessedthermal loads at the vacuum chamber housing caused by scattering electrons inMonte Carlo simulations and FEA. Further,we discuss active cooling strategiesand present a design of the rotating target. |