This title appears in the Scientific Report :
2022
Please use the identifier:
http://hdl.handle.net/2128/33057 in citations.
Please use the identifier: http://dx.doi.org/10.3791/63304 in citations.
Terminal H-reflex Measurements in Mice
Terminal H-reflex Measurements in Mice
The Hoffmann reflex (H-reflex), as an electrical analog to the stretch reflex, allowselectrophysiological validation of the integrity of neural circuits after injuries such asspinal cord damage or stroke. An increase of the H-reflex response, together withsymptoms like non-voluntary muscle contracti...
Saved in:
Personal Name(s): | Wieters, Frederique |
---|---|
Gruhn, Matthias / Büschges, Ansgar / Fink, Gereon R. / Aswendt, Markus (Corresponding author) | |
Contributing Institute: |
Kognitive Neurowissenschaften; INM-3 |
Published in: | JoVE science education, . (2022) 184, S. 63304 |
Imprint: |
Cambridge, MA
JoVE
2022
|
DOI: |
10.3791/63304 |
Document Type: |
Journal Article |
Research Program: |
Multilevel Brain Organization and Variability |
Link: |
Published on 2022-06-16. Available in OpenAccess from 2024-06-16. |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.3791/63304 in citations.
The Hoffmann reflex (H-reflex), as an electrical analog to the stretch reflex, allowselectrophysiological validation of the integrity of neural circuits after injuries such asspinal cord damage or stroke. An increase of the H-reflex response, together withsymptoms like non-voluntary muscle contractions, pathologically augmented stretchreflex, and hypertonia in the corresponding muscle, is an indicator of post-strokespasticity (PSS).In contrast to rather nerve-unspecific transcutaneous measurements, here, we presenta protocol to quantify the H-reflex directly at the ulnar and median nerves of theforepaw, which is applicable, with minor modifications, to the tibial and sciatic nerveof the hindpaw. Based on the direct stimulation and the adaptation to different nerves,the method represents a reliable and versatile tool to validate electrophysiologicalchanges in spasticity-related disease models. |