This title appears in the Scientific Report :
2022
Please use the identifier:
http://hdl.handle.net/2128/33078 in citations.
Please use the identifier: http://dx.doi.org/10.1162/jocn_a_01893 in citations.
Neuropsychological Evidence for a Motor Working Memory Subsystem Related to Apraxia
Neuropsychological Evidence for a Motor Working Memory Subsystem Related to Apraxia
Recent evidence in healthy participants suggests that a motor subcomponent of working memory (mWM) may exist. We investigated whether this mWM is impaired in patients with a motor-dominant left hemisphere (LH) stroke and apraxia. Furthermore, we hypothesized that a deficient mWM contributes to defic...
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Personal Name(s): | Bardakan, Michella M. (Corresponding author) |
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Schmidt, Claudia C. / Hesse, Maike D. / Fink, Gereon R. / Weiss, Peter H. | |
Contributing Institute: |
Kognitive Neurowissenschaften; INM-3 |
Published in: | Journal of cognitive neuroscience, 34 (2022) 11, S. 2016–2027 |
Imprint: |
Cambridge, Mass.
MIT Pr. Journals
2022
|
DOI: |
10.1162/jocn_a_01893 |
Document Type: |
Journal Article |
Research Program: |
Multilevel Brain Organization and Variability |
Link: |
Get full text Published on 2022-10-01. Available in OpenAccess from 2023-01-01. Published on 2022-10-01. Available in OpenAccess from 2023-01-01. |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1162/jocn_a_01893 in citations.
Recent evidence in healthy participants suggests that a motor subcomponent of working memory (mWM) may exist. We investigated whether this mWM is impaired in patients with a motor-dominant left hemisphere (LH) stroke and apraxia. Furthermore, we hypothesized that a deficient mWM contributes to deficits in motor cognition, that is, apraxia, in LH stroke. The study included 52 patients with LH stroke and 25 age-matched controls. Patients were classified into LH stroke patients with and without apraxia based on deficits in gesture imitation and object use. All participants were examined using the block span test (visuospatial WM), the digit span test (verbal WM), and a novel mWM task. In the latter, participants were presented with static pictures depicting three different actions: actions with objects, meaningless actions, and meaningful actions. In the mWM task, LH stroke patients with apraxia performed worse than age-matched controls. Notably, LH stroke patients with apraxia showed more pronounced mWM deficits than those without apraxia. These results remained significant even after controlling for visuospatial and verbal WM deficits. Regression analyses revealed that LH stroke patients' mWM deficits predicted deficits in imitation. Data provide neuropsychological evidence for a motor subsystem of WM and suggest that deficits in mWM contribute to the severity of apraxia in LH stroke patients. |