This title appears in the Scientific Report :
2022
Please use the identifier:
http://dx.doi.org/10.34734/FZJ-2022-04963 in citations.
Please use the identifier: http://dx.doi.org/10.7554/eLife.77215 in citations.
Please use the identifier: http://hdl.handle.net/2128/32755 in citations.
Heritability and cross-species comparisons of human cortical functional organization asymmetry
Heritability and cross-species comparisons of human cortical functional organization asymmetry
The human cerebral cortex is symmetrically organized along large-scale axes but also presents inter-hemispheric differences in structure and function. The quantified contralateral homologous difference, that is asymmetry, is a key feature of the human brain left-right axis supporting functional proc...
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Personal Name(s): | Wan, Bin (Corresponding author) |
---|---|
Bayrak, Şeyma / Xu, Ting / Schaare, H Lina / Bethlehem, Richard AI / Bernhardt, Boris C / Valk, Sofie L | |
Contributing Institute: |
Gehirn & Verhalten; INM-7 |
Published in: | eLife, 11 (2022) S. e77215 |
Imprint: |
Cambridge
eLife Sciences Publications
2022
|
DOI: |
10.34734/FZJ-2022-04963 |
DOI: |
10.7554/eLife.77215 |
Document Type: |
Journal Article |
Research Program: |
Brain Dysfunction and Plasticity |
Link: |
OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.7554/eLife.77215 in citations.
Please use the identifier: http://hdl.handle.net/2128/32755 in citations.
The human cerebral cortex is symmetrically organized along large-scale axes but also presents inter-hemispheric differences in structure and function. The quantified contralateral homologous difference, that is asymmetry, is a key feature of the human brain left-right axis supporting functional processes, such as language. Here, we assessed whether the asymmetry of cortical functional organization is heritable and phylogenetically conserved between humans and macaques. Our findings indicate asymmetric organization along an axis describing a functional trajectory from perceptual/action to abstract cognition. Whereas language network showed leftward asymmetric organization, frontoparietal network showed rightward asymmetric organization in humans. These asymmetries were heritable in humans and showed a similar spatial distribution with macaques, in the case of intra-hemispheric asymmetry of functional hierarchy. This suggests (phylo)genetic conservation. However, both language and frontoparietal networks showed a qualitatively larger asymmetry in humans relative to macaques. Overall, our findings suggest a genetic basis for asymmetry in intrinsic functional organization, linked to higher order cognitive functions uniquely developed in humans. |