This title appears in the Scientific Report :
2023
Please use the identifier:
http://dx.doi.org/10.1021/acsnano.2c05801 in citations.
Please use the identifier: http://hdl.handle.net/2128/33931 in citations.
Membrane-Mediated Interactions Between Nonspherical Elastic Particles
Membrane-Mediated Interactions Between Nonspherical Elastic Particles
The transport of particles across lipid-bilayer membranes is important for biological cells to exchange information and material with their environment. Large particles often get wrapped by membranes, a process which has been intensively investigated in the case of hard particles. However, many part...
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Personal Name(s): | Midya, Jiarul |
---|---|
Auth, Thorsten / Gompper, Gerhard (Corresponding author) | |
Contributing Institute: |
Theoretische Physik der Lebenden Materie; IBI-5 Theorie der Weichen Materie und Biophysik; IAS-2 |
Published in: | ACS nano, 17 (2023) 3, S. 1935–1945 |
Imprint: |
Washington, DC
Soc.
2023
|
DOI: |
10.1021/acsnano.2c05801 |
Document Type: |
Journal Article |
Research Program: |
Molecular Information Processing in Cellular Systems |
Link: |
OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/33931 in citations.
The transport of particles across lipid-bilayer membranes is important for biological cells to exchange information and material with their environment. Large particles often get wrapped by membranes, a process which has been intensively investigated in the case of hard particles. However, many particles in vivo and in vitro are deformable, e.g., vesicles, filamentous viruses, macromolecular condensates, polymer-grafted nanoparticles, and microgels. Vesicles may serve as a generic model system for deformable particles. Here, we study nonspherical vesicles with various sizes, shapes, and elastic properties at initially planar lipid-bilayer membranes. Using the Helfrich Hamiltonian, triangulated membranes, and energy minimization, we predict the interplay of vesicle shapes and wrapping states. Increasing particle softness enhances the stability of shallow-wrapped and deep-wrapped states over nonwrapped and complete-wrapped states. The free membrane mediates an interaction between partial-wrapped vesicles. For the pair interaction between deep-wrapped vesicles, we predict repulsion. For shallow-wrapped vesicles, we predict attraction for tip-to-tip orientation and repulsion for side-by-side orientation. Our predictions may guide the design and fabrication of deformable particles for efficient use in medical applications, such as targeted drug delivery. |