This title appears in the Scientific Report :
2010
Please use the identifier:
http://dx.doi.org/10.1089/rej.2009.0924 in citations.
Differently Selected D-Enantiomeric Peptides Act on Different A beta Species
Differently Selected D-Enantiomeric Peptides Act on Different A beta Species
Aging is the most significant risk factor for Alzheimer disease (AD). The pathological hallmark of AD is the accumulation of aggregated amyloid-beta (Abeta) forms and insoluble plaques, mainly composed of Abeta, in the brain of the patient. Recently, we reported on the selection of D-enantiomeric, A...
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Personal Name(s): | Bartnik, D. |
---|---|
Funke, S. A. / Andrei-Selmer, L.C. / Bacher, M. / Dodel, R. / Willbold, D. | |
Contributing Institute: |
Strukturbiochemie; ISB-3 JARA - HPC; JARA-HPC |
Published in: | Rejuvenation research, 13 (2010) |
Imprint: |
Larchmont, NY
Liebert
2010
|
PubMed ID: |
19954333 |
DOI: |
10.1089/rej.2009.0924 |
Document Type: |
Journal Article |
Research Program: |
BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung Funktion und Dysfunktion des Nervensystems |
Series Title: |
Rejuvenation Research
13 |
Subject (ZB): | |
Publikationsportal JuSER |
Aging is the most significant risk factor for Alzheimer disease (AD). The pathological hallmark of AD is the accumulation of aggregated amyloid-beta (Abeta) forms and insoluble plaques, mainly composed of Abeta, in the brain of the patient. Recently, we reported on the selection of D-enantiomeric, Abeta-binding peptides D1 and D3. D1 was selected against aggregated Abeta species to address diagnosis by in vivo imaging of amyloid plaques, whereas D3 was selected using low-molecular-weight Abeta species, therefore addressing therapeutical studies. Here, we use a surface plasmon resonance method to confirm that both peptides show the desired binding specificities. |