RNA Interference [E-Book] : Challenges and Therapeutic Opportunities / edited by Mouldy Sioud.
RNA Interference: Challenges and Therapeutic Opportunities provides readers with recent advances in siRNA design, delivery, targeting, and methods to minimize siRNA’s unwanted effects. Preclinical and clinical use of synthetic siRNAs, the roles of miRNAs in cancer, and the promise of extracellular m...
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Full text |
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Personal Name(s): | Sioud, Mouldy. editor |
Imprint: |
New York, NY :
Humana Press,
2015
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Physical Description: |
XVI, 495 p. 108 illus., 58 illus. in color. online resource. |
Note: |
englisch |
ISBN: |
9781493915385 |
DOI: |
10.1007/978-1-4939-1538-5 |
Series Title: |
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Methods in molecular biology, methods and protocols ;
1218 |
Subject (LOC): |
- RNA Interference: Mechanisms, Technical Challenges and Therapeutic Opportunities
- Nanostructured RNAs for RNA Interference
- One Long Oligonucleotide or Two Short Oligonucleotides Based shRNA Construction and Expression
- PLGA Microspheres Encapsulating siRNA
- Magnetic Nanoparticle and Magnetic Field Assisted siRNA Delivery In Vitro
- Cytoplasmic Delivery of siRNAs to Monocytes and Dendritic Cells Via Electroporation
- Delivery of siRNAs to Cancer Cells Via Bacteria
- Microwell Array-Mediated Delivery of Lipoplexes Containing Nucleic Acids for Enhanced Therapeutic Efficacy
- Modulating the Tumor Microenvironment with RNA Interference as a Cancer Treatment Strategy
- Targeted In Vivo Delivery of siRNA and an Endosome-Releasing Agent to Hepatocytes
- Cell-Internalization SELEX: Method for Identifying Cell-Internalizing RNA Aptamers for Delivering siRNAs to Target Cells
- Strategies for siRNA Navigation to Desired Cells
- Analysis of RNA Interference-Mediated Hepatic Gene Silencing Following Murine Hydrodynamic Injection of Guanidinopropyl-Modified siRNAs
- Therapy of Respiratory Viral Infections with Intranasal siRNAs
- Engineering Therapeutic Cancer Vaccines that Activate Anti-Tumor Immunity
- Immunosuppressive Factor Blockade in Dendritic Cells Via siRNAs Results in Objective Clinical Responses
- Targeting bcr-abl Transcripts with siRNAs in an Imatinib-Resistant Chronic Myeloid Leukemia Patient: Challenges and Future Directions
- A Facile Method for Interfering with Off-Target Silencing Mediated by the Sense Strand
- Overcoming the Challenges of siRNA Activation of Innate Immunity: Design Better Therapeutic siRNAs
- Gene Silencing In Vitro and In Vivo Using Intronic MicroRNAs
- In Silico Identification of Novel Endo-siRNAs
- Computer-Assisted Annotation of Small RNA Transcriptomes
- miR-CATCH: MicroRNA Capture Affinity Technology
- Roles of MicroRNAs in Cancers and Development
- Targeting MicroRNAs to Withstand Cancer Metastasis
- Urinary MicroRNAs as a New Class of Non-Invasive Biomarkers in Oncology, Nephrology and Cardiology
- Magnetic Bead-Based Isolation of Exosomes
- Modified 2’-Ribose Small RNAs Function as Toll-Like Receptor-7/8 Antagonists.