Cyclin-Dependent Kinase (CDK) Inhibitors [E-Book] : Methods and Protocols / edited by Mar Orzáez, Mónica Sancho Medina, Enrique Pérez-Payá.
This volume contains a collection of relevant information for drug discovery in cell cycle research. Protocols to develop screening assays or to identify novel CDK inhibitors are discussed in the first part of the book. The second part of the book describes elaborate procedures to evaluate activity...
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Full text |
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Personal Name(s): | Orzáez, Mar. editor |
Pérez-Payá, Enrique. editor / Sancho Medina, Mónica. editor | |
Edition: |
1st ed. 2016. |
Imprint: |
New York, NY :
Humana Press,
2016
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Physical Description: |
X, 227 p. 42 illus., 22 illus. in color. online resource. |
Note: |
englisch |
ISBN: |
9781493929269 |
DOI: |
10.1007/978-1-4939-2926-9 |
Series Title: |
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Methods in molecular biology ;
1336 |
Subject (LOC): |
- Immunoprecipitation of CDK-Cyclin Complexes for Determination of Kinase Activity
- Expression and Purification of Recombinant Cyclins and CDKs for Activity Evaluation
- Expression and Purification of Recombinant CDKs: CDK7, CDK8 and CDK9
- Preparation of CDK/Cyclin Inhibitor Complexes for Structural Determination
- Fragment-Based De Novo Design of Cyclin-Dependent Kinase 2 Inhibitors
- Protein-Protein Interaction Inspire the De Novo Design of Cyclin-Dependent Kinases Peptide Inhibitors
- Identification of Cyclin A Binders with a Fluorescent Peptide Sensor
- Cell Synchronization Techniques to Study the Action of CDK Inhibitors
- Analysis of CDK Inhibitors Action on Mitochondria-Mediated Apoptosis
- Evaluating the Effects of CDK Inhibitors in Ischemia-Reperfusion Injury Models
- Assessing Cell Cycle Independent Function of the CDK Inhibitor p21CDKN1A in DNA Repair
- Drug Delivery Strategies of Chemical CDK Inhibitors
- Animal Models for Studying the In Vivo Functions of Cell Cycle CDKs
- Evaluating Chemical CDK Inhibitors as Cell Death Inducers
- Models for the Study of the Crosstalk between Inflammation and Cell Cycle
- Metabolomic Applications to the Characterization of the Mode-of-Action of CDK Inhibitors.