Bacteriophage Applications - Historical Perspective and Future Potential [E-Book] / by Jessica Nicastro, Shirley Wong, Zahra Khazaei, Peggy Lam, Jonathan Blay, Roderick A. Slavcev.
Nicastro, Jessica, (author)
Blay, Jonathan, (author) / Khazaei, Zahra, (author) / Lam, Peggy, (author) / Slavcev, Roderick A., (author) / Wong, Shirley, (author)
Cham : Springer, 2016
VII, 82 p. online resource.
SpringerBriefs in biochemistry and molecular biology
Full Text
Table of Contents:
  • 1. Introduction: What are Bacteriophage: a. Discovery and early phage work (including work with bacterial genetics, phage display, and phage therapy)
  • b. Bacteriophage pathogenesis and host range
  • c. Bacteriophage growth dynamics
  • d. Bacteriophage pharmacokinetics( including mammalian host tolerance )
  • 2. Applications with Bacteriophage: a. Phage Therapy
  • i. Past – why phage therapy was unsuccessful in the past and what can (and is currently) being done to improve the system
  • ii. Present /Future – current research objectives and future considerations
  • Host range and how it can be expanded
  • Lethal agent delivery systems (bacteriocidial)
  • Lethality without lysis
  • b. Phage Vaccines and Phage Immunostimulation
  • i. Mammalian immune response to phage
  • ii. Phage vaccine delivery vehicles
  • iii. Phage Immunotherapy
  • c. Phage as Delivery Vehicles: i. Phage for gene delivery
  • Phage display for specific cell targeting
  • Considerations for use and benefits in comparison to current systems
  • ii. Phage as Drug Carriers
  • Selectivity and cell attachment
  • Phage T2 as a potential cancer therapeutic
  • Phage for delivery to the brain and CNS (including current work with Alzheimer’s and drug addictions )
  • d. Phage for Bacterial Detection: i. History of Phage bacterial detection
  • ii. Methods (replication assays, conjugation with bioluminescence, labelling etc. )
  • iii. Potential uses in healthcare and industry
  • e. Phage for the targeting of Biofilms
  • i. Phage candidates and important bacterial targets
  • ii. History and potential uses in healthcare and industry
  • f. Phage device coatings: i. Current phage coating practices and research
  • ii. Callenges (notably phage orientation)
  • iii. methods to overcome these challenges.