Movement disorders : genetics and models [E-Book] / edited by Mark S. LeDoux.
Saved in:
Full text |
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Personal Name(s): | LeDoux, Mark, editor |
Edition: |
Second edition. |
Imprint: |
London :
Elsevier/Academic Press,
[2015]
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Physical Description: |
1 online resource (xxiii, 1234 pages) : illustrations (some color) |
Note: |
englisch |
ISBN: |
9780124055162 0124055168 |
Subject (LOC): |
- Section I: Scientific foundations. Taxonomy and clinical features of movement disorders
- Modeling disorders of movement
- New transgenic technologies
- Assessment of movement disorders in rodents
- Drosophila
- Use of Caenorhabditis elegans to model human movement disorders
- Zebrafish
- Techniques for motor assessment in rodents
- Induced pluripotent stem cells (iPSCs) to study and treat movement disorders
- Neurophysiologic assessment of movement disorders in humans
- Neurophysiological and optogenetic assessment of brain networks involved in motor control
- Functional imaging to study movement disorders
- Human and nonhuman primate neurophysiology to understand the pathophysiology of movement disorders
- Section II: Parkinson disease. The phenotypic spectrum of Parkinson disease
- genetics and molecular biology of Parkinson disease
- Genotype-phenotype correlations in Parkinson Disease
- From man to mouse: the MPTP model of Parkinson disease
- Rodent models of autosomal dominant Parkinson disease
- Rodent models of autosomal recessive Parkinson disease
- Drosophila models of Parkinson Disease
- Primate models of complications related to Parkinson disease treatment
- Rodent models of treatment-related complications in Parkinson disease
- Methods and models of the nonmotor symptoms of Parkinson disease
- Section III: Dystonia. Dystonia: phenotypes and genetics
- Murine models of caytaxin deficiency
- Animal models of focal dystonia
- Mouse models of dystonia
- Rodent models of autosomal dominant primary dystonia
- Modeling dystonia-parkinsonism
- Section IV: Huntington disease. Genetics of Huntington disease (HD), HD-like disorders, and other choreiform disorders
- Murine models of HD
- Use of genetically engineered mice to study the biology of huntingtin
- Modeling Huntington disease in yeast and invertebrates
- HDL2 mouse
- Analysis of nonmotor features in murine models of Huntington Disease
- Section V: Tremor. Essential tremor
- Use of the harmaline and [alpha]1 knockout models to identify molecular targets for essential tremor
- Physiological and behavioral assessment of tremor in rodents
- Mouse models of the fragile X tremor/ataxia syndrome (FXTAS) and the fragile X premutation
- Section VI: Myoclonus. Myoclonus: Classification, Clinical Features, and Genetics
- Mouse model of Unverricht-Lundborg disease
- Post-hypoxic myoclonus in rodents
- Generating mouse models of mitochondrial disease
- Secion VII: Tics. Tics and Tourette Syndrome: Phenomenology
- Genetics of Tourette syndrome
- Neural circuit abnormalities in Tourette syndrome
- Animal models of Tourette Syndrome and obsessive-compulsive disorder
- Section VIII: Paroxysmal movement disorders. Paroxysmal Movement Disorders: Clinical and Genetic Features
- Mouse models of PNKD
- Glut1 deficiency (G1D)
- Animal models of episodic ataxia type 1 (EA1)
- Mouse models of episodic ataxia type 2.
- Section IX: Tauopathies. Tauopathies: Classification, Clinical Features, and Genetics
- Drosophila models of tauopathy
- Tauopathy mouse models
- Tau protein: biology and pathobiology
- Section X: Other Parkinsonian syndromes: NBIA, MSA, PD + spasticity, PD + dystonia. Clinical Phenomenology and genetics of other parkinsonian syndromes associated with either dystonia or spasticity
- Animal models of multiple-system atrophy
- Modeling PKAN in mice and flies
- Mouse models of FA2H deficiency
- Mouse models of neuroaxonal dystrophy caused by PLA2G6 gene mutations
- Section XI: Ataxias. Genetics and Clinical Features of Inherited Ataxias
- Animal models of spinocerebellar ataxia type 1
- Mouse models of SCA3 and other polyglutamine repeat ataxias
- animal models of Friedreich ataxia
- Ataxia-telangiectasia and the biology of ataxia-telangiectasia mutated (ATM)
- Autosomal recessive ataxias due to defects in DNA repair
- Caenorhabditis elegans models to study the molecular biology of ataxias
- Section XII: Hereditary spastic paraplegia. Hereditary Spastic Paraplegias: Genetics and Clinical Features
- Mouse models of autosomal dominant spastic paraplegia
- Murine models of autosomal recessive hereditary spastic paraplegia
- Modeling hereditary spastic paraplegia (HSP) in zebrafish
- Drosophila models of hereditary spastic paraplegia
- Caenorhabditis elegans models of hereditary spastic paraplegia
- Use of arabidopsis to model hereditary spastic paraplegia and other movement disorders
- Section XIII: Restless legs syndrome. Clinical Phenotype and Genetics of Restless Legs Syndrome
- Combined D3 receptor/iron-deficient mouse model
- Use of Drosophila to study restless legs syndrome
- The A11 lesion/iron deprivation animal model of restless legs syndrome
- Btbd9 knockout mice as a model of restless legs syndrome.