Drug Target miRNA [E-Book] : Methods and Protocols / edited by Marco F. Schmidt.
This volume provides a concise and technical discussion of recently developed approaches to overcome challenges, such as pharmacodynamics and pharmacokinetics difficulties, in miRNA drug discovery. These strategies cover anti-sense agents targeting miRNA that are applied in advanced formulations or...
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Full text |
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Personal Name(s): | Schmidt, Marco F., editor |
Imprint: |
New York, NY :
Humana Press,
2017
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Physical Description: |
XI, 319 p. 94 illus., 62 illus. in color. online resource. |
Note: |
englisch |
ISBN: |
9781493965632 |
DOI: |
10.1007/978-1-4939-6563-2 |
Series Title: |
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Methods in molecular biology ;
1517 |
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- MiRNA Targeting Drugs: The Next Blockbusters?
- Functional Analysis of miRNA using DIANA Tools Online Suite
- Non-Nucleotide Modification of Anti-miRNA Oligonucleotides
- Quantification of Oligonucleotide Association with miRNA-Argonaute Complexes In Vitro
- Determination of Anti-miR Association with miRNA/Argonaute Complexes In Vivo
- Competitive Argonaute-Based RNA Immunoprecipitation for Investigation of Transcriptomic Response to Anti-miR
- Assessing Anti-miR Pharmacology with miRNA Polysome Shift Assay
- Evaluating Synergistic Effects of miR-34a Mimics in Combination with Other Therapeutic Agents in Cultured Non-Small Cell Lung Cancer Cells
- Assessing the Off-Target Effects of miRNA Inhibitors on Innate Immune Toll-Like Receptors
- Design of Multimodal Small Molecules Targeting miRNA Biogenesis: Synthesis and In Vitro Evaluation
- Machine Learning Approaches towards Building Predictive Models for Small Molecule Modulators of miRNA and its Utility in Virtual Screening of Molecular Databases
- Identification of Small Molecule Modulators of MicroRNA by Library Screening
- Rapid Generation of miRNA Inhibitor Leads by Bio-Informatics and Efficient High-Throughput Screening Methods
- Peptide-Based Inhibition of miRNA-Guided Gene Silencing
- Small Molecules Targeting the miRNA Binding Domain of Argonaute 2: From Computer-Aided Molecular Design to RNA Immunoprecipitation
- Surface Plasmon Resonance: A Useful Strategy for the Identification of Small Molecule Argonaute 2 Protein Binders
- Antagonists of the miRNA-Argonaute 2 Protein Complex: Anti-miR-AGOs
- Elucidating Mechanisms of Molecular Recognition between Human Argonaute and miRNA using Computational Approaches
- Kinetic Analysis of Target RNA Binding and Slicing by Argonaute 2 Protein
- Site-Specific Fluorescent Labeling of Argonaute for FRET-Based Bio-Assays
- Single-Molecule Fluorescence Energy Transfer Assays for the Characterization of Reaction Pathways of miRNA-Argonaute Complex.