Huntington’s Disease [E-Book] / edited by Sophie V. Precious, Anne E. Rosser, Stephen B. Dunnett.
This detailed book provides a laboratory manual and guidebook for the selection, implementation, and interpretation of a wide range of techniques in contemporary use in leading laboratories engaged in Huntington’s disease (HD) research worldwide. Only by understanding the pathology and pathogenic pr...
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Full text |
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Personal Name(s): | Dunnett, Stephen B., editor |
Precious, Sophie V., editor / Rosser, Anne E., editor | |
Imprint: |
New York, NY :
Humana Press,
2018
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Physical Description: |
XV, 642 p. 111 illus., 74 illus. in color. online resource. |
Note: |
englisch |
ISBN: |
9781493978250 |
DOI: |
10.1007/978-1-4939-7825-0 |
Series Title: |
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Methods in molecular biology ;
1780 |
Subject (LOC): |
- Stereological Methods to Quantify Cell Loss in the Huntington’s Disease Human Brain
- Assessing Autophagic Activity and Aggregate Formation of Mutant Huntingtin in Mammalian Cells
- A Filter Retardation Assay Facilitates the Detection and Quantification of Heat-Stable, Amyloidogenic Mutant Huntingtin Aggregates in Complex Biosamples
- Cellular Models: HD Patient-Derived Pluripotent Stem Cells
- Non-Mammalian Models of Huntington’s Disease
- Mouse Models of Huntington’s Disease
- Motor Assessment in Huntington’s Disease Mice
- Automated Operant Assessments of Huntington’s Disease Mouse Models
- Neurophysiological Assessment of Huntington’s Disease Model Mice
- Murine Models of Huntington’s Disease for Evaluating Therapeutics
- Generating Excitotoxic Lesion Models of Huntington’s Disease
- Large-Brained Animal Models of Huntington’s Disease: Sheep
- Minipigs as Large-Brained Animal Model for Huntington’s Disease: From Behavior and Imaging to Gene Therapy
- Non-Human Primate Models of Huntington’s Disease and Their Application in Translational Research
- In Vivo Multidimensional Brain Imaging in Huntington’s Disease Animal Models
- Magnetic Resonance Imaging in Huntington’s Disease
- Biofluid Biomarkers in Huntington’s Disease
- Assessing and Modulating Kynurenine Pathway Dynamics in Huntington’s Disease: Focus on Kynurenine 3-Monooxygenase
- Assessing Mitochondrial Function in In Vitro and Ex Vivo Models of Huntington’s Disease
- Using Genomic Data to Find Disease-Modifying Loci in Huntington’s Disease (HD).-CRISPR/Cas9-Mediated Genome Editing for Huntington's Disease
- Methods for Assessing DNA Repair and Repeat Expansion in Huntington’s Disease
- Translating Antisense Technology into a Treatment for Huntington’s Disease
- Disease Modification through Trophic Factor Delivery
- Methods to Quantify Cell Signaling and GPCR Receptor Ligand Bias: Characterization of Drugs that Target the Endocannabinoid Receptors in Huntington’s Disease
- Dissection and Preparation of Human Primary Fetal Ganglionic Eminence Tissue for Research and Clinical Application
- Robust Induction of DARPP32-Expressing GABAergic Striatal Neurons from Human Pluripotent Stem Cells
- Quality Assessment and Production of Human Cells for Clinical Use.