Chimeric Antigen Receptor T Cells [E-Book] : Development and Production / edited by Kamilla Swiech, Kelen Cristina Ribeiro Malmegrim, Virgínia Picanço-Castro.
This volume provides comprehensive methods from expert scientists working in the Chimeric Antigen Receptor T Cell (CAR-T Cell) field. Chapters guide readers through the state-of-art of CAR-T cell technology, CAR design and vector production, CAR-T cell generation and manufacturing, CAR-T cell charac...
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Personal Name(s): | Malmegrim, Kelen Cristina Ribeiro, editor |
Picanço-Castro, Virgínia, editor / Swiech, Kamilla, editor | |
Edition: |
1st edition 2020. |
Imprint: |
New York, NY :
Humana Press,
2020
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Physical Description: |
XI, 274 pages 29 illustrations, 25 illustrations in color (online resource) |
Note: |
englisch |
ISBN: |
9781071601464 |
DOI: |
10.1007/978-1-0716-0146-4 |
Series Title: |
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Methods in Molecular Biology ;
2086 |
Subject (ZB): | |
Subject (LOC): | |
Classification: |
- CAR-T Cells for Cancer Treatment: Current Design and Next Frontiers
- Selection of Antibody Fragments for CAR-T Cell Therapy from Phage Display Libraries
- Phase I/II Manufacture of Lentiviral Vectors under GMP in an Academic Setting
- Production of Lentivirus for the Establishment of CAR-T Cells
- Optimized Production of Lentiviral Vectors for CAR-T Cell
- Lentiviral Vectors Production in Suspension Culture Using Serum-Free Medium for the Transduction of CAR-T Cells
- In vitro Transcribed (IVT)-mRNA CAR Therapy Development
- Generation of Chimeric Antigen Receptor T Cells Using Gammaretroviral Vectors
- Generation of CAR+ T Lymphocytes using the Sleeping Beauty Transposon System
- Platforms for Clinical-grade Car-T Cell Expansion
- CAR-T Cell Expansion in a Xuri Cell Expansion System W25
- Methods and Process Optimization for Large Scale CAR T Expansion Using the G-Rex Cell Culture Platform
- Replication Competent Lentivirus Analysis of Vector Transduced T Cell Products used in Cancer Immunotherapy Clinical Trials
- Immunophenotypic Analysis of CAR-T Cells
- Approaches of T Cell Activation and Differentiation for CAR-T Cell Therapies
- Determination of Cytotoxic Potential of CAR-T Cells in Co-cultivation Assays
- Analysis of CAR-mediated Tonic Signaling
- Generation of Tumor Cells Expressing Firefly Luciferase (fLuc) to Evaluate the Effectiveness of CAR in a Murine Model
- Analysis of Antitumor Effects of CAR-T Cells in Mice with Solid Tumors.