This title appears in the Scientific Report :
2010
Please use the identifier:
http://dx.doi.org/10.1007/s00018-010-0350-6 in citations.
Characterization of the 5-HT(1A) receptor of the honeybee (Apis mellifera) and involvement of serotonin in phototactic behavior
Characterization of the 5-HT(1A) receptor of the honeybee (Apis mellifera) and involvement of serotonin in phototactic behavior
Serotonin plays a key role in modulating various physiological and behavioral processes in both protostomes and deuterostomes. The vast majority of serotonin receptors belong to the superfamily of G-protein-coupled receptors. We report the cloning of a cDNA from the honeybee (Am5-ht1A) sharing high...
Saved in:
Personal Name(s): | Thamm, M. |
---|---|
Balfanz, S. / Scheiner, R. / Baumann, A. / Blenau, W. | |
Contributing Institute: |
Zelluläre Biophysik; ISB-1 |
Published in: | Cellular and molecular life sciences, 67 (2010) S. 2467 - 2479 |
Imprint: |
Basel
Birkhäuser
2010
|
Physical Description: |
2467 - 2479 |
PubMed ID: |
20349263 |
DOI: |
10.1007/s00018-010-0350-6 |
Document Type: |
Journal Article |
Research Program: |
BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung |
Series Title: |
Cellular and Molecular Life Sciences
67 |
Subject (ZB): | |
Publikationsportal JuSER |
Serotonin plays a key role in modulating various physiological and behavioral processes in both protostomes and deuterostomes. The vast majority of serotonin receptors belong to the superfamily of G-protein-coupled receptors. We report the cloning of a cDNA from the honeybee (Am5-ht1A) sharing high similarity with members of the 5-HT(1) receptor class. Activation of Am5-HT(1A) by serotonin inhibited the production of cAMP in a dose-dependent manner (EC(50) = 16.9 nM). Am5-HT(1A) was highly expressed in brain regions known to be involved in visual information processing. Using in vivo pharmacology, we could demonstrate that Am5-HT(1A) receptor ligands had a strong impact on the phototactic behavior of individual bees. The data presented here mark the first comprehensive study-from gene to behavior-of a 5-HT(1A) receptor in the honeybee, paving the way for the eventual elucidation of additional roles of this receptor subtype in the physiology and behavior of this social insect. |