This title appears in the Scientific Report :
2023
Please use the identifier:
http://dx.doi.org/10.1002/mds.29340 in citations.
Please use the identifier: http://dx.doi.org/10.34734/FZJ-2023-01616 in citations.
Dermal Real‐Time Quaking‐Induced Conversion Is a Sensitive Marker to Confirm Isolated Rapid Eye Movement Sleep Behavior Disorder as an Early α‐Synucleinopathy
Dermal Real‐Time Quaking‐Induced Conversion Is a Sensitive Marker to Confirm Isolated Rapid Eye Movement Sleep Behavior Disorder as an Early α‐Synucleinopathy
ABSTRACT:Background:Skin biopsy is apotential tool for the premortem confirmation of anα-synucleinopathy.Objective:The aim was to assess the aggregationassay real-time quaking-induced conversion (RT-QuIC)of skin biopsy lysates to confirm isolated rapid eyemovement sleep behavior disorder (iRBD) as a...
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Personal Name(s): | Kuzkina, Anastasia (First author) |
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Panzer, Celine / Seger, Aline / Schmitt, Daniela / Rößle, Jonas / Schreglmann, Sebastian R. / Knacke, Henrike / Salabasidou, Elena / Kohl, Antonia / Sittig, Elisabeth / Barbe, Michael / Berg, Daniela / Volkmann, Jens / Sommer, Claudia / Oertel, Wolfgang H. / Schaeffer, Eva / Sommerauer, Michael / Janzen, Annette / Doppler, Kathrin (Corresponding author) | |
Contributing Institute: |
Kognitive Neurowissenschaften; INM-3 |
Published in: | Movement disorders, 38 (2023) 6, S. mds.29340 |
Imprint: |
New York, NY
Wiley
2023
|
DOI: |
10.1002/mds.29340 |
DOI: |
10.34734/FZJ-2023-01616 |
Document Type: |
Journal Article |
Research Program: |
Open-Access-Publikationskosten / 2022 - 2024 / Forschungszentrum Jülich (OAPKFZJ) Brain Dysfunction and Plasticity |
Link: |
OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.34734/FZJ-2023-01616 in citations.
ABSTRACT:Background:Skin biopsy is apotential tool for the premortem confirmation of anα-synucleinopathy.Objective:The aim was to assess the aggregationassay real-time quaking-induced conversion (RT-QuIC)of skin biopsy lysates to confirm isolated rapid eyemovement sleep behavior disorder (iRBD) as anα-synucleinopathy.Methods:Skin biopsies of patients with iRBD,Parkinson’s disease (PD), and controls were analyzedusing RT-QuIC and immunohistochemical detection ofphospho-α-synuclein.Results:α-Synuclein aggregation was detected in97.4% of iRBD patients (78.4% of iRBD biopsies),87.2% of PD patients (70% of PD biopsies), and 13%of controls (7.9% of control biopsies), with a higherseeding activity in iRBD compared to PD. RT-QuICwas more sensitive but less specific thanimmunohistochemistry.Conclusions:Dermal RT-QuIC is a sensitive methodto detectα-synuclein aggregation in iRBD, and highseeding activity may indicate a strong involvement ofdermal nervefibers in these patients. © 2023 TheAuthors.Movement Disorderspublished by WileyPeriodicals LLC on behalf of International Parkinsonand Movement Disorder Society.Key Words:rapid eye movement sleep behavior dis-order;α-synuclein; Parkinson’s disease; real-timequaking-induced conversion; skin biopsy |