This title appears in the Scientific Report :
2023
Please use the identifier:
http://dx.doi.org/10.34734/FZJ-2023-01724 in citations.
Morphological and functional characterization of layer 5 neurons in rat medial prefrontal cortex, their synaptic microcircuitry and serotonin modulation
Morphological and functional characterization of layer 5 neurons in rat medial prefrontal cortex, their synaptic microcircuitry and serotonin modulation
Medial prefrontal cortex (Cortex praefrontalis medialis, mPFC) is a part of the association cortex that serves to process and integrate synaptic inputs from sensory and motor cortical areas. The mPFC plays important roles in numerous cognitive processes, such as emotional processing, executive funct...
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Personal Name(s): | Rama, Ramya (Corresponding author) |
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Contributing Institute: |
Jara-Institut Brain structure-function relationships; INM-10 |
Imprint: |
Jülich
Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag
2023
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Physical Description: |
116 |
Dissertation Note: |
Dissertation, RWTH Aachen University, 2022 |
ISBN: |
978-3-95806-688-5 |
DOI: |
10.34734/FZJ-2023-01724 |
Document Type: |
Book Dissertation / PhD Thesis |
Research Program: |
ohne Topic |
Series Title: |
Schriften des Forschungszentrums Jülich Reihe Schlüsseltechnologien / Key Technologies
267 |
Link: |
OpenAccess |
Publikationsportal JuSER |
Medial prefrontal cortex (Cortex praefrontalis medialis, mPFC) is a part of the association cortex that serves to process and integrate synaptic inputs from sensory and motor cortical areas. The mPFC plays important roles in numerous cognitive processes, such as emotional processing, executive function, decision making, spatial orientation, long-term memory and impulse control. Compared to other cortical areas, the mPFC has a particularly high density of serotonergic axons which originate from the dorsal and medial raphe nuclei; they play a crucial role in regulating the development and function of the neocortex. For this reason, a basic knowledge of the role of serotonin (5-HT) and its receptors (5-HTRs) function in the mPFC in modulating cortical activity is crucial. |