This title appears in the Scientific Report :
2023
Please use the identifier:
http://dx.doi.org/10.1002/alz.13056 in citations.
Please use the identifier: http://dx.doi.org/10.34734/FZJ-2023-01786 in citations.
Hippocampal metabolic subregions and networks: Behavioral, molecular, and pathological aging profiles
Hippocampal metabolic subregions and networks: Behavioral, molecular, and pathological aging profiles
INTRODUCTIONHippocampal local and network dysfunction is the hallmark of Alzheimer's disease (AD).METHODSWe characterized the spatial patterns of hippocampus differentiation based on brain co-metabolism in healthy elderly participants and demonstrated their relevance to study local metabolic ch...
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Personal Name(s): | Maleki Balajoo, Somayeh (Corresponding author) |
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Eickhoff, Simon B. / Masouleh, Shahrzad Kharabian / Plachti, Anna / Waite, Laura / Saberi, Amin / Bahri, Mohamed Ali / Bastin, Christine / Salmon, Eric / Hoffstaedter, Felix / Palomero-Gallagher, Nicola / Genon, Sarah | |
Contributing Institute: |
Strukturelle und funktionelle Organisation des Gehirns; INM-1 Gehirn & Verhalten; INM-7 |
Published in: | Alzheimer's and dementia, 19 (2023) 11, S. 4787-4804 |
Imprint: |
Hoboken, NJ
Wiley
2023
|
DOI: |
10.1002/alz.13056 |
DOI: |
10.34734/FZJ-2023-01786 |
Document Type: |
Journal Article |
Research Program: |
Open-Access-Publikationskosten / 2022 - 2024 / Forschungszentrum Jülich (OAPKFZJ) Human Brain Project Specific Grant Agreement 3 JL SMHB - Joint Lab Supercomputing and Modeling for the Human Brain (JL SMHB-2021-2027) Brain Dysfunction and Plasticity Multilevel Brain Organization and Variability |
Link: |
OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.34734/FZJ-2023-01786 in citations.
INTRODUCTIONHippocampal local and network dysfunction is the hallmark of Alzheimer's disease (AD).METHODSWe characterized the spatial patterns of hippocampus differentiation based on brain co-metabolism in healthy elderly participants and demonstrated their relevance to study local metabolic changes and associated dysfunction in pathological aging.RESULTSThe hippocampus can be differentiated into anterior/posterior and dorsal cornu ammonis (CA)/ventral (subiculum) subregions. While anterior/posterior CA show co-metabolism with different regions of the subcortical limbic networks, the anterior/posterior subiculum are parts of cortical networks supporting object-centered memory and higher cognitive demands, respectively. Both networks show relationships with the spatial patterns of gene expression pertaining to cell energy metabolism and AD's process. Finally, while local metabolism is generally lower in posterior regions, the anterior–posterior imbalance is maximal in late mild cognitive impairment with the anterior subiculum being relatively preserved.DISCUSSIONFuture studies should consider bidimensional hippocampal differentiation and in particular the posterior subicular region to better understand pathological aging. |